PADI2 Antibody [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Janelia Fluor 549

PADI2 Antibody [Janelia Fluor® 549] Summary

• Immunogen: E. coli-derived recombinant human PADI2
  Met1-Ala115
  Accession # Q9Y2J8
• Specificity: Detects human PADI2 in direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: PADI2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for PADI2 Antibody [Janelia Fluor® 549]

• EC 3.5.3.15
• KIAA0994PDI2PAD2
• PAD2
• PAD-H19
• PADI2
• PDI2
• peptidlyarginine deiminase type II
• peptidyl arginine deiminase, type II
• Peptidylarginine Deiminase II
• protein arginine deiminase
• Protein-arginine deiminase type II
• protein-arginine deiminase type-2

Background

PADI2 / PAD2 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. Each family member has a distinct substrate specificity and tissue expression pattern. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative disorders, including Alzheimers disease and multiple sclerosis, and it has also been implicated in the pathogenesis of glaucoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PADI2