PADI2 Products

Description

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.

Bioinformatics

Entrez	11240 Human
Uniprot	NP_031391.2 Human
Product By Gene ID	11240
Alternate Names	EC 3.5.3.15 KIAA0994PDI2PAD2 PAD2 PAD-H19 PADI2 PDI2 peptidlyarginine deiminase type II peptidyl arginine deiminase, type II Peptidylarginine Deiminase II protein arginine deiminase Protein-arginine deiminase type II protein-arginine deiminase type-2

Research Areas for PADI2

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Amino Acids, Drugs and other small molecules
Neurodegeneration
Neuroscience
Signal Transduction