OSCAR Antibody (259501)

• Reactivity: Hu
• Applications: WB
• Clone: 259501
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

OSCAR Antibody (259501) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human OSCAR isoform 2
  Asp19-Asn229 (Asn158Ser)
  Accession # Q8IYS5
• Specificity: Detects human OSCAR in direct ELISAs and Western blots. In Western blots, this antibody does not cross-react with recombinant mouse OSCAR.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: OSCAR
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for OSCAR Antibody (259501)

• hOSCAR
• MGC33613
• OSCAR
• osteoclast associated receptor OSCAR-S1
• osteoclast associated receptor OSCAR-S2
• osteoclast associated, immunoglobulin-like receptor
• osteoclast-associated immunoglobulin-like receptor
• Osteoclast-associated receptor
• PIGR3
• PIgR-3
• Poly-Ig receptor 3
• Polymeric immunoglobulin receptor 3

Background

OSCAR is a type I membrane protein that belongs to the leukocyte receptor complex (LRC) protein family. It is expressed specifically in preosteoclasts and mature osteoclasts. OSCAR may be an important regulator of osteoclast differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for OSCAR Antibody (MAB2004)(1)

Publication using MAB2004

• Herman S, Muller RB, Kronke G, Zwerina J, Redlich K, Hueber AJ, Gelse H, Neumann E, Muller-Ladner U, Schett G Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. Arthritis Rheum., 2008-10-01;58(10):3041-50. 2008-10-01 [PMID: 18821671] (ELISA Development, Human)

Bioinformatics

• Gene Symbol: OSCAR
• Uniprot:
  • Q8IYS5()