Oct-3/4 Antibody (240408) [Alexa Fluor™ Plus 647]

• Reactivity: Hu, Mu
• Clone: 240408
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 647

Oct-3/4 Antibody (240408) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Oct-3/4 in Western blots and detects mouse Oct-3/4 in flow cytometry.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Oct-3/4 Antibody (240408) [Alexa Fluor™ Plus 647]

• 3-Oct
• Oct-3/4
• OCT3;Oct-3;OCT4;Oct-4;OCT4;Oct3/4;OTF3;OTF-3;OTF4;POU domain protein;POU domain, class 5, transcription factor 1;POU5F1
• Oct4
• Otf3g
• Otf4
• Pou5f1

Background

Oct-3/4, also termed Oct-3 or Oct-4, is a POU transcription factor that is expressed in totipotent embryonic stem and germ cells.(2, 3) Oct-3/4 is required to sustain stem cell self-renewal and pluripotency.(4) It is considered a master regulator of pluripotency that controls lineage commitment and is the most widely recognized marker of totipotent embryonic stem cells.

1. Takeda, J. et al. (1992) Nucleic Acids Res. 20:4613.
2. Scholer, H.R. et al. (1989) EMBO J. 8:2543.
3. Rosner, M.H. et al. (1990) Nature 345:686.
4. Niwa, H. et al. (2000) Nat. Genet. 24:372.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.