Oct-3/4 Antibody (240408) [Phycoerythrin]

• Applications: Flow
• Clone: 240408
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Phycoerythrin

Oct-3/4 Antibody (240408) [Phycoerythrin] Summary

• Immunogen: E. coli-derived recombinant human Oct‑3/4
  Met1-Asn265 (Met262Leu)
  Accession # Q01860
• Specificity: Detects human Oct-3/4 in Western blots and detects mouse Oct-3/4 in flow cytometry.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: POU5F1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Oct-3/4, also termed Oct-3 or Oct-4, is a POU transcription factor that is expressed in totipotent embryonic stem and germ cells (1- 3). Oct-3/4 is required to sustain stem cell self-renewal and pluripotency (4). It is considered a master regulator of pluripotency that controls lineage commitment and is the most widely recognized marker of totipotent embryonic stem cells.

1. Takeda, J. et al. (1992) Nucleic Acids Res. 20:4613.
2. Scholer, H.R. et al. (1989) EMBO J. 8:2543.
3. Rosner, M.H. et al. (1990) Nature 345:686.
4. Niwa, H. et al. (2000) Nat. Genet. 24:372.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: POU5F1