OATP1B3/SLCO1B3/OATP8 Antibody (CL3771) - Azide and BSA Free

Staining of human liver shows strong membranous immunoreactivity in hepatocytes.

Staining of human skeletal muscle shows absence of immunoreactivity (negative control).

• Reactivity: Hu
• Applications: IHC
• Clone: CL3771
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: LYOPH

OATP1B3/SLCO1B3/OATP8 Antibody (CL3771) - Azide and BSA Free Summary

• Immunogen: This antibody was generated using a recombinant protein sequence of Q9NPD5, with the exact immunogen sequence remaining proprietary.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: SLCO1B3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin 1:500 - 1:10000
• Application Notes: IHC-Paraffin HIER pH6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered solution in PBS with Trehalose
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein A purified
• Reconstitution Instructions: Centrifuge the vial of lyophilized antibody at 12,000 x g for 20 seconds. Reconstitute by adding sterile, distilled water to achieve a final antibody concentration of 1mg/ml.

Alternate Names for OATP1B3/SLCO1B3/OATP8 Antibody (CL3771) - Azide and BSA Free

• Liver-specific organic anion transporter 2
• liver-specific organic anion transporter 3TM13
• LST2
• LST-2
• LST3
• OATP1B3
• OATP1B3LST-3TM13
• OATP8
• OATP-8
• Organic anion transporter 8
• organic anion transporter LST-3c
• Organic anion-transporting polypeptide 8
• SLC21A8
• SLCO1B3
• solute carrier family 21 (organic anion transporter), member 8
• Solute carrier family 21 member 8
• solute carrier organic anion transporter family member 1B3
• solute carrier organic anion transporter family, member 1B3

Background

The OATPs (organic anion transporter polypeptides) are a family of transport proteins that have been found to mediate the uptake of organic ions into hepatocyte cells. These proteins fall into the solute carrier family 21A (SLC21A), and are expressed in liver, kidney, and brain. These polypeptides are involved in the excretion of potentially toxic compounds and therefore play a role in the overall detoxification system of the body. Unlike other members of the OATP family, OATP2 and 8 have been detected exclusively in the liver, and there is an 80% amino acid sequence homology between these polypeptides. Other names for OATP2 include SLC21A6, OATP-C, and LST-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLCO1B3