Immunocytochemistry/ Immunofluorescence: OATP2/8 Antibody (MDQ) [NB100-74482] - Analysis of OATP8 in HepG2 Cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed ...read more
This product was originally labeled as an antibody to OATP8. However, the amino acid sequence used as the immunizing peptide is 100% identical to OATP2. Furthermore, publications using this antibody show reactivity to both OATP2 and 8. As such, this antibody is reactive to both OATP2 and OATP8.
Alternate Names for OATP2/8 Antibody (MDQ)
SLCO1B1 solute carrier organic anion transporter family, member 1B1
The OATPs (organic anion transporter polypeptides) are a family of transport proteins that have been found to mediate the uptake of organic ions into hepatocyte cells. These proteins fall into the solute carrier family 21A (SLC21A), and are expressed in liver, kidney, and brain. These polypeptides are involved in the excretion of potentially toxic compounds and therefore play a role in the overall detoxification system of the body. Unlike other members of the OATP family, OATP2 and 8 have been detected exclusively in the liver, and there is an 80% amino acid sequence homology between these polypeptides. Other names for OATP2 include SLC21A6, OATP-C, and LST-1.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for OATP2/8 Antibody (NB100-74482). (Showing 1 - 1 of 1 FAQs).
The customer is very confused with product name of #NB100-74482. SLC01B3(MDQ/5F260) was indicated on the vial label. SLC01B3 is alternative name of OATP8. But OATP2(MDQ) was indicated on the datasheet on your web. Furthermore, when the customer searched 5F260 on your web, #NB600-1158 (OATP8 Antibody (5F260)) appeared. I think something is wrong for #NB100-74482. Could you confirm the product name of suppliers' and let us know? As far as I looked the Internet, Clone MDQ reacts with both OATP2 and OATP8. Clone 5F260 also reacts with both OATP2 and OATP8? Is MDQ identical with 5F260?
Clone MDQ and clone 5F260 are two separate clones generated using the same immunogen. Both are also predicted to react with both OATP2 and OATP8, based on the sequence similarity.
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Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.