OATP1B3/SLCO1B3/OATP8 Products

Description

The OATPs (organic anion transporter polypeptides) are a family of transport proteins that have been found to mediate the uptake of organic ions into hepatocyte cells. These proteins fall into the solute carrier family 21A (SLC21A), and are expressed in liver, kidney, and brain. These polypeptides are involved in the excretion of potentially toxic compounds and therefore play a role in the overall detoxification system of the body. Unlike other members of the OATP family, OATP2 and 8 have been detected exclusively in the liver, and there is an 80% amino acid sequence homology between these polypeptides. Other names for OATP2 include SLC21A6, OATP-C, and LST-1.

Bioinformatics

Uniprot	NP_062818.1 Human Q9NPD5 Human
Product By Gene ID	28234
Alternate Names	Liver-specific organic anion transporter 2 liver-specific organic anion transporter 3TM13 LST2 LST-2 LST3 OATP1B3LST-3TM13 OATP8 OATP8 OATP-8 Organic anion transporter 8 organic anion transporter LST-3c Organic anion-transporting polypeptide 8 SLC21A8 SLC21A8 solute carrier family 21 (organic anion transporter), member 8 Solute carrier family 21 member 8 solute carrier organic anion transporter family member 1B3 solute carrier organic anion transporter family, member 1B3

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OATP8 - A membrane transport protein responsible for cancer drug uptake Human hepatocytes express important transport proteins that are responsible for the uptake and removal of organic anions from the blood. These proteins are members of the organic anion-transporting polypeptide (OATP) family and are essential for pr...    Read more.

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