Nurr1/NGFI-B beta/NR4A2 Antibody

Images

 
Western Blot: Nurr1 Antibody [NB110-40415] - Western blot detection of Nurr1 in 20 ug of human hippocampus tissue lysate (lanes 2 and 4) with Nurr1 polyclonal at 1:1000 dilution followed by AP-conjugated secondary at ...read more
Immunohistochemistry: Nurr1 Antibody [NB110-40415] - Nurr1 staining with Nurr1 polyclonal antibody at a 1:100 dilution in adult rat brain hippocampus. Tissue was fixed in paraformaldehyde and cut into 20 micron sections.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Nurr1/NGFI-B beta/NR4A2 Antibody Summary

Immunogen
Synthetic peptide comprising residues 513-526 [TERHGLKEPKRVEE] of the human Nurr1 protein. Based on 100% sequence homology, this antibody is also expected to cross react with rat and mouse Nurr1.
Specificity
This is specific to the Nurr1 protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NR4A2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500- 1:2000
  • Immunohistochemistry 1:100-1:200
  • Immunoprecipitation
Application Notes
This antibody is useful for Western Blot and Immunohistochemistry. Use in Immunoprecipitation reported in scientific literature (PMID 18784308)
Control
Nurr1/NGFI-B beta/NR4A2 Overexpression Lysate
Reviewed Applications
Read 1 Review rated 5
using
NB110-40415 in the following applications:

Publications
Read Publication using
NB110-40415 in the following applications:

  • IP
    1 publication

Reactivity Notes

Human and Rat. Other species not yet tested. Mouse reactivity reported in scientific literature (PMID: 18784308).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Nurr1/NGFI-B beta/NR4A2 Antibody

  • human homolog of
  • NGFI-B beta
  • NOT
  • NR4A2
  • nuclear receptor subfamily 4, group A, member 2
  • Nurr1
  • orphan nuclear receptor NR4A2
  • Orphan nuclear receptor NURR1
  • T-cell nuclear receptor NOT
  • TINUR
  • transcriptionally inducible nuclear receptor related 1
  • Transcriptionally-inducible nuclear receptor

Background

The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's. Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype. In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Nurr1/NGFI-B beta/NR4A2 Antibody (NB110-40415)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IP.


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IP
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Review for Nurr1/NGFI-B beta/NR4A2 Antibody (NB110-40415) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using NB110-40415:
Filter by Applications
IHC-P
(1)
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Filter by Species
Mouse
(1)
All Species
Images Ratings Applications Species Date Details
 
reviewed by:
Anonymous
IHC-P Mouse 05/23/2018
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample Testedjoints
SpeciesMouse
Lot2930

Comments

Commentsantigen retrieval
working concentration: 4ug/mL

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Control Lysate(s)

Secondary Antibodies

 

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Recent Reviews

5
5
1
4
0
3
0
2
0
1
0

 
Anonymous
05/23/2018
Application: IHC-P
Species: Mouse

Bioinformatics

Gene Symbol NR4A2
Entrez