NR4A3/NOR1 Antibody - BSA Free

Immunohistochemistry-Paraffin: NR4A3/NOR1 Antibody [NLS2341] - Pancreas, carcinoma

Immunohistochemistry-Paraffin: NR4A3/NOR1 Antibody [NLS2341] - Analysis of anti-Nor-1 / NR4A3 antibody with human brain, neurons and glia.

Immunohistochemistry-Paraffin: NR4A3/NOR1 Antibody [NLS2341] - Analysis of anti-Nor-1 / NR4A3 antibody with human skin, melanoma.

Immunohistochemistry-Paraffin: NR4A3/NOR1 Antibody [NLS2341] - Ovary, Carcinoma

Immunohistochemistry-Paraffin: NR4A3/NOR1 Antibody [NLS2341] - Prostate, Carcinoma

• Reactivity: Hu, Mu, Bt, Ca, Pm, Rt, Bv, Ha, Pm, Rb
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

NR4A3/NOR1 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 20 aa peptide from near C-terminus of human NR4A3/NOR1.
• Epitope: Near C-Terminus
• Specificity: Human NR4A3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Rat (95%), Hamster (95%), Primate (100%), Bovine (95%), Rabbit (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NR4A3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 - 20 ug/ml
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (95%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for NR4A3/NOR1 Antibody - BSA Free

• CHN
• CSMF
• MINOR
• NOR1
• TEC

Background

NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant. NOR-1 expression has been documented in human brain, heart, placenta, kidney, skeletal muscle, fetal brain and fetal lung. ESTs have been isolated from human tissue libraries, including cancerous head/neck and skin, and normal prostate, skin, liver, testis, skeletal muscle, blood and B-cell/lung/testis. Caution: The symbol NOR-1 is also used to describe a nitric oxide-donor reagent. Tec is also the name of a kinase on chromosome 4.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for NR4A3/NOR1 Antibody (NLS2341)(3)

Publications using NLS2341

• Servaas NH, Hiddingh S, Chouri E et al. Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+?Dendritic Cell Dysregulation in Systemic Sclerosis Arthritis & rheumatology (Hoboken, N.J.) 2023-02-01 [PMID: 36482877] (Immunohistochemistry-Paraffin)
• Nomiyama T, Zhao Y, Gizard F et al. Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Circulation. 2009-02-03 [PMID: 19153266] (IHC-P, Mouse)
  
  Details:
  IHC (paraffin), mouse heart tissue, Fig. 1A.
• Nomiyama T, Nakamachi T, Gizard F et al. The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation. J Biol Chem. 2006-11-03 [PMID: 16945922] (IHC-P)
  
  Details:
  IHC-paraffin; human coronary arteries, Fig 1: (IF: NOR1 transfected cells, Supplemental Fig. 1). The specificity of the NOR-1 antibody has been validated by IF using overexpressed NOR1 in HEk293 cells, Supplemental Fig 1.

Bioinformatics

• Gene Symbol: NR4A3
• Entrez:
  • 8013(Human)
• Uniprot:
  • Q92570(Human)