Nurr1/NGFI-B beta/NR4A2 Antibody

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

Nurr1/NGFI-B beta/NR4A2 Antibody Summary

Immunogen
E. coli-derived recombinant mouse Nurr1/NGFI‑B beta /NR4A2
Val332-Lys558
Accession # Q06219
Specificity
Detects human and mouse Nurr1/NGFI‑B beta /NR4A2 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
NR4A2
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Immunohistochemistry 5-15 ug/mL
Publications
Read Publications using
AF2156 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Nurr1/NGFI-B beta/NR4A2 Antibody

  • human homolog of
  • NGFI-B beta
  • NOT
  • NR4A2
  • nuclear receptor subfamily 4, group A, member 2
  • Nurr1
  • orphan nuclear receptor NR4A2
  • Orphan nuclear receptor NURR1
  • T-cell nuclear receptor NOT
  • TINUR
  • transcriptionally inducible nuclear receptor related 1
  • Transcriptionally-inducible nuclear receptor

Background

Nurr1 belongs to the nerve growth factor-induced clone B subfamily of nuclear receptor superfamily and is designated NR4A2 in the Unified Nomenclature System for NRs. Nurr1 can function as a ligand-independent transcription factor. Nurr1 also heterodimerizes with retinoid X receptors (RXRs) to function as ligand-regulated transcription factor. Nurr1 is important for specification of dopaminergic neurons that degenerate in Parkinson’s disease. Human and mouse Nurr1 share 99% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Nurr1/NGFI-B beta/NR4A2 Antibody (AF2156)(5)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: IHC, IHC-Fr, Western Blot.


Filter By Application
IHC
(3)
IHC-Fr
(1)
Western Blot
(1)
All Applications
Filter By Species
Human
(1)
Mouse
(3)
Rat
(1)
All Species
Showing Publications 1 - 5 of 5.
Publications using AF2156 Applications Species
RC Sellnow, K Steece-Col, F Altwal, IM Sandoval, JH Kordower, TJ Collier, CE Sortwell, AR West, FP Manfredsso Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease J. Neurosci., 2020;40(18):3675-3691. 2020 [PMID: 32238479] (IHC, Rat) IHC Rat
Y Arai, AW Cwetsch, E Coppola, S Cipriani, H Nishihara, H Kanki, Y Saillour, B Freret-Hod, A Dutriaux, N Okada, H Okano, C Dehay, J Nardelli, P Gressens, T Shimogori, G D'Onofrio, A Pierani Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex Cell Rep, 2019;29(3):645-658.e5. 2019 [PMID: 31618633] (IHC-Fr, Human) IHC-Fr Human
K Onishi, A Uyeda, M Shida, T Hirayama, T Yagi, N Yamamoto, N Sugo Genome Stability by DNA polymerase ? in Neural Progenitors Contributes to Neuronal Differentiation in Cortical Development J. Neurosci., 2017;0(0):. 2017 [PMID: 28765330] (IHC, Mouse) IHC Mouse
Pedraza M, Hoerder-Suabedissen A, Albert-Maestro M, Molnar Z, De Carlos J Extracortical origin of some murine subplate cell populations. Proc Natl Acad Sci U S A, 2014;111(23):8613-8. 2014 [PMID: 24778253] (IHC, Mouse) IHC Mouse
Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Circulation, 2009;119(4):577-86. 2009 [PMID: 19153266] (Western Blot, Mouse) Western Blot Mouse

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Bioinformatics

Gene Symbol NR4A2
Uniprot