NHE8 Antibody (7A11) [FITC]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF
Clone
7A11
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

NHE8 Antibody (7A11) [FITC] Summary

Immunogen
A fusion protein containing the C-terminal 89 residues of human NHE8. [Swiss-Prot# Q9Y2E8]
Localization
Golgi apparatus membrane; multi-pass membrane.
Specificity
This is specific for the 85 kDa mature glycosylated form of the protein. It does not recognize the 55 kDa immature form.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
SLC9A8
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
Application Notes
This NHE8 antibody is useful for Western blot analysis where a band is seen at ~80 kDa. Please note that these samples should not be boiled.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, mouse and rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for NHE8 Antibody (7A11) [FITC]

  • DKFZp686C03237
  • KIAA0939DKFZp686C03237
  • MGC138418
  • Na(+)/H(+) exchanger 8
  • NHE-8
  • NHE8FLJ42500
  • sodium/hydrogen exchanger 8
  • solute carrier family 9 (sodium/hydrogen exchanger)
  • solute carrier family 9 (sodium/hydrogen exchanger), isoform 8
  • solute carrier family 9 (sodium/hydrogen exchanger), member 8
  • Solute carrier family 9 member 8

Background

NHE (Na+/H+ Exchanger) family members are integral membrane proteins which have been identified to play a key role in catalyzing the extrusion of intracellular proton (H+) ions in exchange for extracellular sodium (Na+) ions for regulation of cellular pH as well as transepithelial ion/water transport. NHE8 is a relatively new member of Na+/H+ exchanger family and is a ubiquitously expressed protein with highest levels detected in epithelial cells of the intestine and the kidney as well as in skeletal muscles. Interestingly, the intestinal/renal expression levels of NHE8 are significantly higher than that of NHE2/NHE3 at a young age, suggesting that NHE8 as an important player for sodium absorption during early development. Localized mainly in Golgi apparatus membranes as multi-pass membrane protein, NHE8 is implicated in regulation of pH to eliminate acids generated by active metabolism or to counter adverse environmental conditions. NHE8 is a major proton extruding system driven by the inward sodium ion chemical gradient and has also been proposed to play role in signaling mechanisms also.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB110-62091B
DyLight 350 Labeled NB110-62091UV
DyLight 405 Labeled NB110-62091V
DyLight 488 Labeled NB110-62091G
DyLight 550 Labeled NB110-62091R
DyLight 650 Labeled NB110-62091C
DyLight 680 Labeled NB110-62091FR
DyLight 755 Labeled NB110-62091IR
HRP Labeled NB110-62091H

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Bioinformatics

Gene Symbol SLC9A8