NALP12 Products

NALP12 Antibody
NALP12 Antibody
Species: Hu, Mu, Rt, V
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
NALP12 Antibody
NALP12 Antibody
Species: Hu
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
NALP12 Antibody
NALP12 Antibody
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
NALP12 Overexpression Lysate
NALP12 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human NALP12 GST ...
Recombinant Human NALP12 GST (N-Te...
Species: Hu
Applications: WB, ELISA, PA, AP
NALP12 Recombinant Protein An ...
NALP12 Recombinant Protein Antigen
Species: Hu
Applications: AC
NALP12 Antibody Blocking Pept ...
NALP12 Antibody Blocking Peptide
Species: Hu
Applications: AC


NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes. NALP12 may mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.


Uniprot Human
Product By Gene ID 91662
Alternate Names
  • FCAS2
  • Monarch-1
  • NACHT, leucine rich repeat and PYD containing 12
  • NACHT, LRR and PYD domains-containing protein 12
  • NALP12LRR and PYD containing protein 12
  • NLR family, pyrin domain containing 12
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 12
  • PYPAF7Monarch1
  • PYRIN-containing APAF1-like protein 7
  • Regulated by nitric oxide
  • RNO2

Research Areas for NALP12

Find related products by research area and learn more about each of the different research areas below.


PTMs for NALP12

Learn more about PTMs related to NALP12.


Bioinformatics Tool for NALP12

Discover related pathways, diseases and genes to NALP12. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related NALP12 Blog Posts

Check out the latest blog posts on NALP12.
Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release
By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.
Read more NALP12 related blogs.