NALP12 Antibody - BSA Free

• Reactivity: Hu
• Applications: WB, IHC, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

NALP12 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit NALP12 Antibody - BSA Free (NB100-56157) is a polyclonal antibody validated for use in IHC, WB and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A synthetic peptide corresponding to amino acids 190-208 ([BLAST]QASPIKIETLFEPDEERPE[/BLAST]) of human NALP12/PYPAF7/Monarch-1 was used as immunogen (NP_653288).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NLRP12
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:1000-1:5000
  • Immunoprecipitation 1:50-1:200
  • Western Blot 1:1000-1:2000
• Control:

  NALP12 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: 0.05% Sodium Azide
• Purity: Unpurified

Alternate Names for NALP12 Antibody - BSA Free

• FCAS2
• Monarch-1
• NACHT, leucine rich repeat and PYD containing 12
• NACHT, LRR and PYD domains-containing protein 12
• NALP12LRR and PYD containing protein 12
• NLR family, pyrin domain containing 12
• nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 12
• PYPAF7Monarch1
• PYRIN-containing APAF1-like protein 7
• Regulated by nitric oxide
• RNO2

Background

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes. NALP12 may mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NLRP12
• Entrez:
  • 91662(Human)
• Uniprot:
  • P59046(Human)