MYH6 Antibody (940344) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB, IHC, ICC/IF
• Clone: 940344
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

MYH6 Antibody (940344) [Alexa Fluor® 647] Summary

• Immunogen: Human MYH6 peptide
  Accession # P13533
• Specificity: Detects human MYH6. The peptide immunogen sequence represents a region specific to MYH6 and not present in other MYH isoforms.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MYH6 Antibody (940344) [Alexa Fluor® 647]

• alpha-MHC
• ASD3
• cardiomyopathy
• CMD1EE
• CMH14
• Hypertrophic 1
• MYH6
• MYHC
• MYHCA
• MyHC-Alpha
• Myosin Heavy Chain 6
• Myosin Heavy Chain, Cardiac Muscle Alpha Isoform
• Myosin, Heavy Chain 6, Cardiac Muscle, Alpha
• Myosin, Heavy Polypeptide 6, Cardiac Muscle, Alpha (Cardiomyopathy, Hypertrophic 1)
• Myosin-6
• SSS3

Background

The MYH6 gene encodes the alpha chain of cardiac myosin, a muscle motor protein with two regions that bind actin at aa 657-679 and 759-773. Defects in this gene cause atrial septal defect 3, hypertrophic cardiac myopathy and sick sinus syndrome. MYH6 participates in embryonic and adult heart development and muscle contraction.  In adult heart, the beta chain isoform predominates in the ventricular tissue, while both isoforms are found in variable proportions in atrial tissue.  Force development is much faster in atrial tissue and ATP consumption is much higher.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.