MSX2 Antibody - BSA Free

Immunohistochemistry-Paraffin: MSX2 Antibody [NBP1-85445] - Staining of human placenta shows strong nuclear positivity in trophoblastic cells.

Immunohistochemistry-Paraffin: MSX2 Antibody [NBP1-85445] - Staining of human urinary bladder shows weak nuclear positivity in urothelial cells.

Immunohistochemistry-Paraffin: MSX2 Antibody [NBP1-85445] - Staining of human endometrium shows moderate nuclear positivity in glandular cells.

Immunohistochemistry-Paraffin: MSX2 Antibody [NBP1-85445] - Staining of human liver shows low positivity in hepatocytes as expected.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

MSX2 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: SSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPRHTSPTTCTLRKHKTNRKP
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MSX2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  MSX2 Protein (NBP1-85445PEP)

Reactivity Notes

Mouse, Rat (86%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for MSX2 Antibody - BSA Free

• CRS2
• CRS2parietal foramina 1
• FPP
• Homeobox protein Hox-8
• homeobox protein MSX-2
• Hox8
• HOX8msh homeobox homolog 2 (Drosophila)
• msh (Drosophila) homeo box homolog 2
• msh homeo box 2
• msh homeobox 2
• msh homeobox homolog 2
• MSH
• MSX2
• PFM
• PFM1

Background

Msx2/Hox8 encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MSX2 Antibody (NBP1-85445)(4)

Publications using NBP1-85445

• Nagy A, Peth? D, Gesztelyi R et al. BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate International Journal of Molecular Sciences 2021-08-26 [PMID: 34502172]
• Wirrig EE, Hinton RB, Yutzey KE. Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves. J Mol Cell Cardiol 2011-03-01 [PMID: 21163264]
• Mulder J, Bjorling E, Jonasson K et al. Tissue Profiling of the Mammalian Central Nervous System Using Human Antibody-based Proteomics. Mol Cell Proteomics 2009-07-01 [PMID: 19351664]
• Wensman H, Goransson H, Leuchowius KJ et al. Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas. Breast Cancer Res Treat 2009-11-01 [PMID: 19048371]

Bioinformatics

• Gene Symbol: MSX2