Mouse/Rat Leptin Quantikine ELISA Kit, 2 Plate

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Mouse/Rat Leptin Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Mouse Leptin Immunoassay is a 4.5 hour solid phase ELISA designed to measure soluble mouse leptin in cell culture supernates, serum*, and plasma. It contains recombinant mouse leptin expressed in E. coli and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse leptin accurately. Results obtained measurin...g natural mouse leptin showed dose-response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse leptin.
  
  *Pregnant mouse serum from the second trimester of pregnancy through post-partum day 1 require acid/urea activation of mouse leptin.
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• Specificity: Natural and recombinant mouse and rat Leptin. This assay cross-reacts 0.24% with Human Leptin.
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Lep

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat Leptin Quantikine ELISA Kit, 2 Plate

• FLJ94114
• LEP
• leptin (murine obesity homolog)
• leptin (obesity homolog, mouse)
• Leptin
• OB
• Obese protein
• obese, mouse, homolog of
• Obesity factor
• OBOBS

Background

Leptin is a product of the mouse obese gene. Mice with mutations in the obese gene that block the synthesis of leptin are obese and diabetic, and have reduced activity, metabolism, and body temperature. Rat leptin shares approximately 96% and 82% sequence identity with the mouse and human protein, respectively. The expression of leptin mRNA is restricted to adipose tissue.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Leptin/OB (MOB00)(183)

Publications using MOB00

• Ma, T;Wang, J;Sun, G;Li, K;Qu, H;Wang, Y;Li, S;Wu, B; Irisin and liraglutide combination therapy mitigates myocardial reperfusion injury in obese rats: Role of endoplasmic reticulum stress and apoptosis Archives of biochemistry and biophysics 2025-03-04 [PMID: 40049268] (Rat)
• Sato, H;Taketomi, Y;Murase, R;Park, J;Hosomi, K;Sanada, TJ;Mizuguchi, K;Arita, M;Kunisawa, J;Murakami, M; Group X phospholipase A2 links colonic lipid homeostasis to systemic metabolism via host-microbiota interaction Cell reports 2024-09-17 [PMID: 39298315] (Transgenic Mouse)
• Duquenne, M;Deligia, E;Folgueira, C;Bourouh, C;Caron, E;Pfrieger, F;Schwaninger, M;Nogueiras, R;Annicotte, JS;Imbernon, M;Prévot, V; Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice Molecular metabolism 2024-07-22 [PMID: 39047908] (Mouse)
• Mohr, SM;Dai Pra, R;Platt, MP;Feketa, VV;Shanabrough, M;Varela, L;Kristant, A;Cao, H;Merriman, DK;Horvath, TL;Bagriantsev, SN;Gracheva, EO; Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation Nature communications 2024-07-10 [PMID: 38987241] (Squirrel)
• DI Cho, MJ Ahn, HH Cho, M Cho, JH Jun, BG Kang, SY Lim, SJ Yoo, MR Kim, HS Kim, SJ Lee, LT Dat, C Lee, YS Kim, Y Ahn ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation Experimental & Molecular Medicine, 2023-02-13;0(0):. 2023-02-13 [PMID: 36782020] (Mouse)
• T Hirabayash, M Kawaguchi, S Harada, M Mouri, R Takamiya, Y Miki, H Sato, Y Taketomi, K Yokoyama, T Kobayashi, SM Tokuoka, Y Kita, E Yoda, S Hara, K Mikami, Y Nishito, N Kikuchi, R Nakata, M Kaneko, H Kiyonari, K Kasahara, T Aiba, K Ikeda, T Soga, M Kurano, Y Yatomi, M Murakami Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups Cell Reports, 2023-01-30;42(2):111940. 2023-01-30 [PMID: 36719796] (Mouse)
• S Raia, A Conti, A Zanardi, B Ferrini, GM Scotti, E Gilberti, G De Palma, S David, M Alessio Ceruloplasmin-Deficient Mice Show Dysregulation of Lipid Metabolism in Liver and Adipose Tissue Reduced by a Protein Replacement International Journal of Molecular Sciences, 2023-01-06;24(2):. 2023-01-06 [PMID: 36674661] (Mouse)
• N Cuesta, S Fernández-, C Punzón, C Moreno, B Barrocal, V Sreeramkum, M Desco, M Fresno Opposing Actions of TLR2 and TLR4 in Adipocyte Differentiation and Mature-Onset Obesity International Journal of Molecular Sciences, 2022-12-10;23(24):. 2022-12-10 [PMID: 36555322] (Mouse)
• D Chamseddin, SA Mahmud, AK Westfall, TA Castoe, RE Berg, MW Pellegrino The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response Cell Reports, 2022-12-13;41(11):111789. 2022-12-13 [PMID: 36516750] (Mouse)
• S Yuan, KS Stewart, Y Yang, MD Abdusselam, SM Parigi, TY Feinberg, K Tumaneng, H Yang, JM Levorse, L Polak, D Ng, E Fuchs Ras drives malignancy through stem cell crosstalk with the microenvironment Nature, 2022-11-30;0(0):. 2022-11-30 [PMID: 36450983] (Mouse)
• SH Seo, D Lee, SH Lee, KY Choi Blockade of CXXC5-dishevelled interaction inhibits adipogenic differentiation, obesity, and insulin resistance in mice Scientific Reports, 2022-11-30;12(1):20669. 2022-11-30 [PMID: 36450849] (Mouse)
• S Ahn, M Ahn, S Park, S An, IG Park, SY Hwang, J Gong, S Oh, SH Jin, HJ Kim, JH Cheong, Y Byun, M Noh Discovery of PPARgamma and glucocorticoid receptor dual agonists to promote the adiponectin and leptin biosynthesis in human bone marrow mesenchymal stem cells European Journal of Medicinal Chemistry, 2022-11-10;245(0):114927. 2022-11-10 [PMID: 36379105] (Mouse)
• UK Goand, S Verma, AP Gupta, R Garg, S Dadge, JR Gayen Pancreastatin inhibitor PSTi8 balances energy homeostasis by attenuating adipose tissue inflammation in high fat diet fed mice Peptides, 2022-11-11;159(0):170902. 2022-11-11 [PMID: 36375661] (Mouse)
• DK Lee, T Kim, J Byeon, M Park, S Kim, J Kim, S Choi, G Lee, C Park, KW Lee, YJ Kwon, JH Lee, YG Kwon, YM Kim REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-kappaB activation Nature Communications, 2022-10-22;13(1):6303. 2022-10-22 [PMID: 36272977] (Mouse)
• CJ Chen, CC Wu, CY Chang, JR Li, YC Ou, WY Chen, SL Liao, JD Wang Metformin Mitigated Obesity-Driven Cancer Aggressiveness in Tumor-Bearing Mice International Journal of Molecular Sciences, 2022-08-15;23(16):. 2022-08-15 [PMID: 36012397] (Mouse)
• N Melnikov, Y Kamari, M Kandel-Kfi, I Barshack, A Ben-Amotz, D Harats, A Shaish, A Harari beta-Carotene from the Alga Dunaliella bardawil Decreases Gene Expression of Adipose Tissue Macrophage Recruitment Markers and Plasma Lipid Concentrations in Mice Fed a High-Fat Diet Marine Drugs, 2022-06-29;20(7):. 2022-06-29 [PMID: 35877726] (Mouse)
• M Alonso-Ber, A Asensio, A Palou-Marc, J Sánchez, A Palou, F Serra, M Palou Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats International Journal of Molecular Sciences, 2022-06-29;23(13):. 2022-06-29 [PMID: 35806240] (Rat)
• B Reynés, M Cifre, A Palou, P Oliver Perinatal Treatment with Leptin, but Not Celastrol, Protects from Metabolically Obese, Normal-Weight Phenotype in Rats Nutrients, 2022-05-29;14(11):. 2022-05-29 [PMID: 35684076] (Rat)
• MH Do, MJ Oh, HB Lee, CH Kang, G Yoo, HY Park Bifidobacterium animalis ssp. lactis MG741 Reduces Body Weight and Ameliorates Nonalcoholic Fatty Liver Disease via Improving the Gut Permeability and Amelioration of Inflammatory Cytokines Nutrients, 2022-05-07;14(9):. 2022-05-07 [PMID: 35565930] (Mouse)
• CA Pomar, C Picó, A Palou, J Sánchez Maternal Consumption of a Cafeteria Diet during Lactation Leads to Altered Diet-Induced Thermogenesis in Descendants after Exposure to a Western Diet in Adulthood Nutrients, 2022-05-07;14(9):. 2022-05-07 [PMID: 35565926] (Rat)
• AD McNeilly, A Yianakas, JG Gallagher, J Tarlton, ML Ashford, RJ McCrimmon Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion Molecular Metabolism, 2022-04-22;61(0):101488. 2022-04-22 [PMID: 35470093] (Mouse)
• YY Sung, SH Kim, DS Kim Combined Phyllostachys pubescens and Scutellaria baicalensis Prevent High-Fat Diet-Induced Obesity via Upregulating Thermogenesis and Energy Expenditure by UCP1 in Male C57BL/6J Mice Nutrients, 2022-01-19;14(3):. 2022-01-19 [PMID: 35276805] (Mouse)
• J Dereke, E Ekblad, B Weström, C Erlanson-A, M Landin-Ols, I Sjöholm, M Hillman Structural and immunoendocrine remodeling in gut, pancreas and thymus in weaning rats fed powdered milk diets rich in Maillard reactants Scientific Reports, 2022-03-08;12(1):4039. 2022-03-08 [PMID: 35260716] (Rat)
• L Zizmare, CN Boyle, S Buss, S Louis, L Kuebler, K Mulay, R Krüger, L Steinhauer, I Mack, M Rodriguez, K Herfert, Y Ritze, C Trautwein Roux-En-Y Gastric Bypass (RYGB) Surgery during High Liquid Sucrose Diet Leads to Gut Microbiota-Related Systematic Alterations International Journal of Molecular Sciences, 2022-01-20;23(3):. 2022-01-20 [PMID: 35163046] (Rat)
• B Xue, Y Yu, TG Beltz, F Guo, SG Wei, AK Johnson Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension-Induced Hypertensive Response Sensitization Elicited by Postweaning High-Fat Diet in Female Offspring Journal of the American Heart Association, 2022-01-11;11(2):e023685. 2022-01-11 [PMID: 35014859] (Rat)
• JA Thompson, K Krajnak, RA Johnston, ML Kashon, W McKinney, JS Fedan High-fat western diet-consumption alters crystalline silica-induced serum adipokines, inflammatory cytokines and arterial blood flow in the F344 rat Toxicology reports, 2021-12-07;9(0):12-21. 2021-12-07 [PMID: 34976743] (Rat)
• P Castillo, M Palou, ZX Yau-Qiu, AM Rodríguez, A Palou, C Picó Myo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effects Nutrients, 2021-09-18;13(9):. 2021-09-18 [PMID: 34579137] (Rat)
• B Xue, Y Yu, TG Beltz, F Guo, RB Felder, SG Wei, A Kim Johnso Maternal Angiotensin II-Induced Hypertension Sensitizes Postweaning High-Fat Diet-Elicited Hypertensive Response Through Increased Brain Reactivity in Rat Offspring Journal of the American Heart Association, 2021-09-06;0(0):e022170. 2021-09-06 [PMID: 34482712] (Rat)
• P Dhanraj, MB van Heerde, MS Pepper, MA Ambele Sexual Dimorphism in Changes That Occur in Tissues, Organs and Plasma during the Early Stages of Obesity Development Biology, 2021-07-28;10(8):. 2021-07-28 [PMID: 34439950] (Mouse)
• B Leibiger, T Moede, I Valladolid, M Paschen, M Visa, IB Leibiger, PO Berggren Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of ob/ob Mice Metabolites, 2021-06-14;11(6):. 2021-06-14 [PMID: 34198579] (Mouse)
• G Tavares, D Marques, C Barra, D Rosendo-Si, A Costa, T Rodrigues, P Gasparini, BF Melo, JF Sacramento, R Seiça, SV Conde, P Matafome Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes Molecular Metabolism, 2021-04-29;0(0):101241. 2021-04-29 [PMID: 33933677] (Rat)
• B Grases-Pin, M Abril-Gil, P Torres-Cas, M Castell, MJ Rodríguez-, FJ Pérez-Cano, À Franch Rat Milk and Plasma Immunological Profile throughout Lactation Nutrients, 2021-04-11;13(4):. 2021-04-11 [PMID: 33920419] (Rat)
• JE Pruett, ED Torres Fer, SJ Everman, RM Vinson, K Davenport, MK Logan, SA Ye, DG Romero, LL Yanes Card Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome International Journal of Molecular Sciences, 2021-03-04;22(5):. 2021-03-04 [PMID: 33806551] (Rat)
• N Shrestha, J Vidimce, OJ Holland, JSM Cuffe, BR Beck, AV Perkins, AJ McAinch, DH Hryciw Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner International Journal of Molecular Sciences, 2021-03-14;22(6):. 2021-03-14 [PMID: 33799409] (Rat)
• JD Plummer, SD Postnikoff, JK Tyler, JE Johnson Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice Elife, 2021-03-30;10(0):. 2021-03-30 [PMID: 33783357] (Mouse)
• Z Zhang, X Chen, YJ Loh, X Yang, C Zhang The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice Bmc Biology, 2021-03-19;19(1):51. 2021-03-19 [PMID: 33740961] (Mouse)
• REM Júnior, LM de Carvalh, D Carlos Dos, GD Cassali, AMC Faria, TU Maioli, ALB Godard Diet-induced obesity leads to alterations in behavior and gut microbiota composition in mice The Journal of nutritional biochemistry, 2021-03-08;0(0):108622. 2021-03-08 [PMID: 33705942] (Mouse)
• FJ Ruiz-Ojeda, J Wang, T Bäcker, M Krueger, S Zamani, S Rosowski, T Gruber, Y Onogi, A Feuchtinge, TJ Schulz, R Fässler, TD Müller, C García-Các, M Meier, M Blüher, S Ussar Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis Molecular Metabolism, 2021-01-07;45(0):101147. 2021-01-07 [PMID: 33359386] (Mouse)
• JG Wagner, CE Barkauskas, A Vose, RP Lewandowsk, JR Harkema, RM Tighe Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains Environmental health perspectives, 2020-11-30;128(11):117009. 2020-11-30 [PMID: 33253011] (Mouse)
• M Portero-Tr, D Rojic-Beck, C Vega-Carba, G Guillazo-B, A Vale-Martí, M Martí-Nico Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats Sci Rep, 2020-11-09;10(1):19299. 2020-11-09 [PMID: 33168891] (Rat)
• J Song, J Kim, HJ Park, H Kim Anti-Obesity Effects of a Prunus persica and Nelumbo nucifera Mixture in Mice Fed a High-Fat Diet Nutrients, 2020-11-04;12(11):. 2020-11-04 [PMID: 33158191] (Mouse)
• Verena Peek, Elena Neumann, Tomohiro Inoue, Sandy Koenig, Fabian Johannes Pflieger, Rüdiger Gerstberger et al. Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists Frontiers in Immunology 2020-08-19 [PMID: 32973755] (Rat)
• T Nemoto, T Nakakura, Y Kakinuma Elevated blood pressure in high-fat diet-exposed low birthweight rat offspring is most likely caused by elevated glucocorticoid levels�due to abnormal pituitary negative feedback PLoS ONE, 2020-08-27;15(8):e0238223. 2020-08-27 [PMID: 32853260] (Rat)
• ZX Yau-Qiu, C Picó, AM Rodríguez, A Palou Leptin Distribution in Rat Foetal and Extraembryonic Tissues in Late Gestation: A Physiological View of Amniotic Fluid Leptin Nutrients, 2020-08-21;12(9):. 2020-08-21 [PMID: 32825787] (Rat)
• CA Pomar, J Sánchez, A Palou The Intake of a Cafeteria Diet in Nursing Rats Alters the Breast Milk Concentration of Proteins Important for the Development of Offspring Nutrients, 2020-08-17;12(8):. 2020-08-17 [PMID: 32824434] (Rat)
• FT Spradley High-fat diet from parental generation exaggerates body and adipose tissue weights in pregnant offspring PLoS ONE, 2020-08-20;15(8):e0237708. 2020-08-20 [PMID: 32817646] (Rat)
• LY Herat, NC Ward, AL Magno, EP Rakoczy, MG Kiuchi, MP Schlaich, VB Matthews Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice World J. Gastroenterol., 2020-06-21;26(23):3225-3235. 2020-06-21 [PMID: 32684737] (Mouse)
• NA Al-Sawalha, Y Almahmmod, MS Awawdeh, KH Alzoubi, OF Khabour Effect of waterpipe tobacco smoke exposure on the development of metabolic syndrome in adult male rats PLoS ONE, 2020-06-19;15(6):e0234516. 2020-06-19 [PMID: 32559253] (Rat)
• RS Bergmans, M Nikodemova, VJ Stull, A Rapp, KMC Malecki Comparison of cricket diet with peanut-based and milk-based diets in the recovery from protein malnutrition in mice and the impact on growth, metabolism and immune function PLoS ONE, 2020-06-11;15(6):e0234559. 2020-06-11 [PMID: 32525953] (Mouse)
• YM Chao, KLH Wu, PC Tsai, YL Tain, S Leu, WC Lee, JYH Chan Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure J. Biomed. Sci., 2020-05-23;27(1):68. 2020-05-23 [PMID: 32446297] (Rat)
• DC Fernandez, R Komal, J Langel, J Ma, PQ Duy, MA Penzo, H Zhao, S Hattar Retinal innervation tunes circuits that drive nonphotic entrainment to food Nature, 2020-04-22;581(7807):194-198. 2020-04-22 [PMID: 32404998] (Mouse)
• H Sato, Y Taketomi, Y Miki, R Murase, K Yamamoto, M Murakami Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ?3 Polyunsaturated Fatty Acids in WAT Cell Rep, 2020-05-05;31(5):107579. 2020-05-05 [PMID: 32375030] (Mouse)
• J Zhai, S Li, M Hu, F Di, J Liu, Y Du Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome Reprod. Biol. Endocrinol., 2020-04-25;18(1):32. 2020-04-25 [PMID: 32334629] (Rat)
• S Park, HK Son, HC Chang, JJ Lee Effects of Cabbage-Apple Juice Fermented by Lactobacillus plantarum EM on Lipid Profile Improvement and Obesity Amelioration in Rats Nutrients, 2020-04-18;12(4):. 2020-04-18 [PMID: 32325640] (Rat)
• C Xiao, N Liu, H Province, RA Piñol, O Gavrilova, ML Reitman BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice Mol Metab, 2020-02-29;36(0):100969. 2020-02-29 [PMID: 32229422] (Mouse)
• RJ Perry, K Lyu, A Rabin-Cour, J Dong, X Li, Y Yang, H Qing, A Wang, X Yang, GI Shulman Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk J. Clin. Invest., 2020-04-01;130(4):2001-2016. 2020-04-01 [PMID: 32149734] (Rat)
• D Nuzzaci, C Cansell, F Liénard, E Nédélec, S Ben Fradj, J Castel, E Foppen, R Denis, D Grouselle, A Laderrière, A Lemoine, A Mathou, V Tolle, T Heurtaux, X Fioramonti, E Audinat, L Pénicaud, JL Nahon, C Rovère, A Benani Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal Cell Rep, 2020-03-03;30(9):3067-3078.e5. 2020-03-03 [PMID: 32130907] (Mouse)
• SK Hsieh, NH Lin, YJ Chen, MR Lee, WY Chen, JTC Tzen Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet Molecules, 2020-02-22;25(4):. 2020-02-22 [PMID: 32098371] (Rat)
• N Kawao, Y Takafuji, M Ishida, K Okumoto, H Morita, M Muratani, H Kaji Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice PLoS ONE, 2020-02-03;15(2):e0228685. 2020-02-03 [PMID: 32012199] (Mouse)
• S Hoshino, M Kobayashi, R Tagawa, R Konno, T Abe, K Furuya, K Miura, H Wakasawa, N Okita, Y Sudo, Y Mizunoe, Y Nakagawa, T Nakamura, H Kawabe, Y Higami WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole body glucose metabolism FEBS Open Bio, 2020-02-03;0(0):. 2020-02-03 [PMID: 31965758] (Mouse)
• CI Gil, M Ost, J Kasch, S Schumann, S Heider, S Klaus Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice Sci Rep, 2019-12-27;9(1):20120. 2019-12-27 [PMID: 31882966] (Mouse)
• V Frodermann, D Rohde, G Courties, N Severe, MJ Schloss, H Amatullah, CS McAlpine, S Cremer, FF Hoyer, F Ji, ID van Koever, F Herisson, L Honold, GS Masson, S Zhang, J Grune, Y Iwamoto, SP Schmidt, GR Wojtkiewic, IH Lee, K Gustafsson, G Pasterkamp, SCA de Jager, RI Sadreyev, J MacFadyen, P Libby, P Ridker, DT Scadden, K Naxerova, KL Jeffrey, FK Swirski, M Nahrendorf Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells Nat. Med., 2019-11-07;25(11):1761-1771. 2019-11-07 [PMID: 31700184] (Mouse)
• N Kawao, M Ishida, H Kaji Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice PLoS ONE, 2019-10-24;14(10):e0224403. 2019-10-24 [PMID: 31648235] (Mouse)
• P Siriarchav, MC Kruger, MR Miller, HS Tian, FM Wolber The Preventive Effects of Greenshell Mussel (Perna canaliculus) on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity Nutrients, 2019-07-15;11(7):. 2019-07-15 [PMID: 31311115] (Rat)
• C Gougoula, AP Bielfeld, SJ Pour, M Sager, JS Krüssel, WPM Benten, DM Baston-Büs Metabolic and behavioral parameters of mice with reduced expression of Syndecan-1 PLoS ONE, 2019-07-12;14(7):e0219604. 2019-07-12 [PMID: 31299063] (Mouse)
• AB Silva Risc, NIP Neto, K Gascho, M Carnier, DA de Miranda, FP Silva, VT Boldarine, M Seelaender, EB Ribeiro, LM Oyama, CM Oller do N A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells PLoS ONE, 2019-06-18;14(6):e0218567. 2019-06-18 [PMID: 31211796] (Rat)
• R Tazawa, K Uchida, H Fujimaki, M Miyagi, G Inoue, H Sekiguchi, K Murata, K Takata, A Kawakubo, M Takaso Elevated leptin levels induce inflammation through IL-6 in skeletal muscle of aged female rats BMC Musculoskelet Disord, 2019-05-10;20(1):199. 2019-05-10 [PMID: 31077169] (Rat)
• JA Deis, H Guo, Y Wu, C Liu, DA Bernlohr, X Chen Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration Mol Metab, 2019-03-20;0(0):. 2019-03-20 [PMID: 30928474] (Mouse)
• E ?ebrowska, M Maciejczyk, M ?endzian-P, A Zalewska, A Chabowski High Protein Diet Induces Oxidative Stress in Rat Cerebral Cortex and Hypothalamus Int J Mol Sci, 2019-03-28;20(7):. 2019-03-28 [PMID: 30925663] (Rat)
• M Pierard, A Tassin, S Conotte, K Zouaoui Bo, A Legrand Sustained Intermittent Hypoxemia Induces Adiponectin Oligomers Redistribution and a Tissue-Specific Modulation of Adiponectin Receptor in Mice Front Physiol, 2019-02-08;10(0):68. 2019-02-08 [PMID: 30800074] (Mouse)
• A Bodur, ? ?nce, C Kahraman, ? Abidin, S Aydin-Abid, A Alver Chronically reduced BDNF levels increase oxidative stress in epididymal, but not subcutaneous, adipose tissue following high sucrose and high fat diets fed mice Arch. Biochem. Biophys., 2019-02-21;0(0):. 2019-02-21 [PMID: 30797748] (Mouse)
• CS Seo, SR Yoo, SJ Jeong, H Ha Quantification of the constituents of the traditional Korea medicine, Samryeongbaekchul-san, and assessment of its antiadipogenic effect Saudi Pharm J, 2018-09-11;27(1):145-153. 2018-09-11 [PMID: 30662318] (Mouse)
• G Wang, N Mohammadtu, Y Lv, H Zhang, J Sun, J Dong Baicalin Exerts Anti-Airway Inflammation and Anti-Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease Evid Based Complement Alternat Med, 2018-10-08;2018(0):7591348. 2018-10-08 [PMID: 30402133] (Rat)
• D Kain, AJ Simon, A Greenberg, D Ben Zvi, B Gilburd, J Schneiderm Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction PLoS ONE, 2018-10-12;13(10):e0203902. 2018-10-12 [PMID: 30312306] (Mouse)
• A Mosqueda-S, J Sánchez, B Reynés, M Palou, MP Portillo, A Palou, C Picó Hesperidin and capsaicin, but not the combination, prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats Sci Rep, 2018-10-10;8(1):15100. 2018-10-10 [PMID: 30305645] (Rat)
• KA Philbrick, AJ Branscum, CP Wong, RT Turner, UT Iwaniec Leptin Increases Particle-Induced Osteolysis in Female ob/ob Mice Sci Rep, 2018-10-04;8(1):14790. 2018-10-04 [PMID: 30287858] (Mouse)
• A Tazi, JR Araujo, C Mulet, ET Arena, G Nigro, T Pédron, PJ Sansonetti Disentangling Host-Microbiota Regulation of Lipid Secretion by Enterocytes: Insights from Commensals Lactobacillus paracasei and Escherichia coli MBio, 2018-09-04;9(5):. 2018-09-04 [PMID: 30181250] (Mouse)
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FAQs for Leptin/OB (MOB00). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Lep