TIM-1/KIM-1/HAVCR Antibody [Unconjugated]


Western blot shows lysates of NIH‑3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse TIM‑1/KIM‑1/HAVCR Antigen Affinity-purified Polyclonal Antibody (Catalog # ...read more

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Reactivity MuSpecies Glossary
Applications WB

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TIM-1/KIM-1/HAVCR Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant mouse TIM‑1/KIM-1/HAVCR
Accession # NP_001160104
Detects mouse TIM‑1/KIM-1/HAVCR in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human TIM-1, recombinant mouse (rm) TIM-2, rmTIM-3, rmTIM-4, rmTIM-6, and rmTIM-7 is observed.
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.25 ug/mL
Read Publications using
AF1817 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TIM-1/KIM-1/HAVCR Antibody [Unconjugated]

  • CD365
  • HAVCR1
  • HAVCR-1
  • HAVCRT cell immunoglobin domain and mucin domain protein 1
  • hepatitis A virus cellular receptor 1
  • Kidney injury molecule 1
  • KIM1
  • KIM-1
  • T-cell immunoglobulin and mucin domain-containing protein 1
  • TIM1
  • TIM-1
  • TIM-1TIM
  • TIM1TIMD-1
  • TIMD1T-cell membrane protein 1


TIM-1 (T cell-immunoglobulin-mucin; also KIM-1 and HAVCR) is a 70-80 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules (1-4). This gene family is involved in the regulation of Th1 and Th2-cell-mediated immunity. In mouse, there are eight known TIM genes (# 1-8) vs. only three genes in human (# 1, 3, and 4) (1, 2). Mouse TIM-1 and -2 are counterparts of human TIM-1 while mouse TIM-5 through 8 have no human counterparts (2). Mouse TIM-1 is synthesized as a 305 amino acid (aa) precursor that contains a 21 aa signal sequence, a 216 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 47 aa cytoplasmic domain (5, 6). The ECD contains one V-type Ig-like domain and a mucin region characterized by multiple T-S-P motifs. The mucin region undergoes extensive O-linked glycosylation. The mouse TIM-1 gene is highly polymorphic and, based on rat, may undergo alternate splicing (4, 6). For instance, HBA mice show a 15 aa deletion in the mucin region that occurs in BALB/c mice (6). This difference is associated with a decreased susceptibility to asthma. Other polymorphisms are also documented (6). In human, TIM-1 is known to circulate as a soluble form. It undergoes constitutive cleavage by an undefined MMP, releasing a 75-85 kDa soluble molecule (5). The same thing might be expected in mouse. The ECD of mouse TIM-1 is 50%, 39%, and 80% aa identical to human, canine and rat TIM-1 ECD, respectively. The only two reported ligands for TIM-1 are TIM-4 and the hepatitis A virus (8, 9). However, others are believed to exist, and based on the ligand for TIM-3, one possibility might be an S-type lectin (10). TIM-1 ligation induces T cell proliferation and promotes cytokine production (1, 10). In particular, it induces IL-4 production, and requires the cytoplasmic tyrosine phosphorylation motif (5).

  1. Meyers, J.H. et al. (2005) Trends Mol. Med. 11:1471. 
  2. Kuchroo, V.K. et al. (2003) Nat. Rev. Immunol. 3:454. 
  3. Mariat, C. et al. (2005) Phil. Trans. R. Soc. B 360:1681.  
  4. Ichimura, T. et al. (1998) J. Biol. Chem. 273:4135.  
  5. de Souza, A.J. et al. (2005) Proc. Natl. Acad. Sci. USA 102:17113. 
  6. McIntire, J.J. et al. (2001) Nat. Immunol. 2:1109.
  7. Bailly, V. et al. (2002) J. Biol. Chem. 277:39739.
  8. Feigelstock, D. et al. (1998) J. Virol. 72:6621.
  9. Zhu, C. et al. (2005) Nat. Immunol. 6:1245.
  10. Meyers, J.H. et al. (2005) Nat. Immunol. 6:455.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TIM-1/KIM-1/HAVCR Antibody (AF1817)(39)

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 6 applications: Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, Western Blot.

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Showing Publications 1 - 10 of 39. Show All 39 Publications.
Publications using AF1817 Applications Species
K Hoeft, GJL Schaefer, H Kim, D Schumacher, T Bleckwehl, Q Long, BM Klinkhamme, F Peisker, L Koch, J Nagai, M Halder, S Ziegler, E Liehn, C Kuppe, J Kranz, S Menzel, I Costa, A Wahida, P Boor, RK Schneider, S Hayat, R Kramann Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner Cell Reports, 2023-02-17;42(2):112131. 2023-02-17 [PMID: 36807143] (IHC, Mouse) IHC Mouse
Z Zhao, G Li, Y Wang, Y Li, H Xu, W Liu, W Hao, Y Yao, R Zeng Cytoplasmic HMGB1 induces renal tubular ferroptosis after ischemia/reperfusion International immunopharmacology, 2023-02-01;116(0):109757. 2023-02-01 [PMID: 36731154] (IHC, Transgenic Mouse) IHC Transgenic Mouse
X Cao, J Wang, T Zhang, Z Liu, L Liu, Y Chen, Z Li, Y Zhao, Q Yu, T Liu, J Nie, Y Niu, Y Chen, L Yang, L Zhang Chromatin accessibility dynamics dictate renal tubular epithelial cell response to injury Nature Communications, 2022-11-28;13(1):7322. 2022-11-28 [PMID: 36443310] (IHC, Mouse) IHC Mouse
S Ide, K Ide, K Abe, Y Kobayashi, H Kitai, J McKey, SA Strausser, LL O'Brien, A Tata, PR Tata, T Souma Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair Cell Reports, 2022-11-08;41(6):111610. 2022-11-08 [PMID: 36351395] (IHC, Transgenic Mouse) IHC Transgenic Mouse
LS Dalbøge, M Christense, MR Madsen, T Secher, N Endlich, V Drenic', A Manresa-Ar, HH Hansen, I Rune, LN Fink, MV Østergaard Nephroprotective Effects of Semaglutide as Mono- and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease Biomedicines, 2022-07-11;10(7):. 2022-07-11 [PMID: 35884965] (IHC, Mouse) IHC Mouse
MJ Livingston, S Shu, Y Fan, Z Li, Q Jiao, XM Yin, MA Venkatacha, Z Dong Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis Autophagy, 2022-05-18;0(0):. 2022-05-18 [PMID: 35491858] (IHC, Mouse) IHC Mouse
T Eckes, S Patyna, A Koch, A Oftring, S Gauer, N Obermüller, S Schwalm, L Schaefer, J Chun, HJ Gröne, J Pfeilschif Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy International Journal of Molecular Sciences, 2022-04-02;23(7):. 2022-04-02 [PMID: 35409312] (Western Blot, Mouse) Western Blot Mouse
TH Shen, J Stauber, K Xu, A Jacunski, N Paragas, M Callahan, R Banlengchi, AD Levitman, B Desanti de, A Beenken, MS Grau, E Mathieu, Q Zhang, Y Li, T Gopal, N Askanase, S Arumugam, S Mohan, PI Good, JS Stevens, F Lin, SK Sia, CS Lin, V D'Agati, K Kiryluk, NP Tatonetti, J Barasch Snapshots of nascent RNA reveal cell- and stimulus- specific responses to acute kidney injury JCI Insight, 2022-03-22;0(0):. 2022-03-22 [PMID: 35230973] (IHC, Mouse) IHC Mouse
EA Telford, AJ Sanders, S Owen, F Ruge, GM Harrison, WG Jiang, TA Martin Hepatitis A Virus Cellular Receptor 1 (HAVcr-1) Initiates Prostate Cancer Progression in Human Cells via Hepatocyte Growth Factor (HGF)-Induced Changes in Junctional Integrity Biomolecules, 2022-02-21;12(2):. 2022-02-21 [PMID: 35204839] (Western Blot, Human) Western Blot Human
S Wang, K Jing, H Wu, X Li, C Yang, T Li, H Tang, T Zou, Y She, HF Liu Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy Oxidative Medicine and Cellular Longevity, 2022-01-12;2022(0):2812493. 2022-01-12 [PMID: 35082964] (IHC, Mouse) IHC Mouse
Show All 39 Publications.

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Gene Symbol HAVCR1