Mouse IL-17A/F Heterodimer DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-17A/F Heterodimer DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-17A/F Heterodimer DuoSet ELISA, 15 Plate

• CTLA8
• CTLA8cytotoxic T-lymphocyte-associated serine esterase 8
• Cytotoxic T-lymphocyte-associated antigen 8
• Cytotoxic T-Lymphocyte-Associated Protein 8
• IL17
• IL-17
• IL-17A
• IL-17A/F Heterodimer
• interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
• interleukin 17A
• interleukin-17A

Background

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Publications for IL-17A/F Heterodimer (DY5390)(10)

Publications using DY5390

• Zeydabadinejad, S;Kim, JSA;Zheng, A;Kandalgaonkar, MR;Ababio, PB;Vijay-Kumar, M;Yeoh, BS;Saha, P; Targeting anemia-induced CD71+ reticulocytes protects mice from Plasmodium infection Infection and Immunity 2025-07-01 [PMID: 40590713] (Mouse)
• H Wang, Y Li, Z Yue, Y Liu, Q Chen, D Hu, J Han Adipose-Derived Stem Cell Exosomes Inhibit Hypertrophic Scaring Formation by Regulating Th17/Treg Cell Balance BioMed Research International, 2022-10-12;2022(0):9899135. 2022-10-12 [PMID: 36277890] (Mouse)
• M Arabpour, C Lebrero-Fe, K Schön, A Strömberg, V Börjesson, K Lahl, M Ballegeer, X Saelens, D Angeletti, W Agace, N Lycke ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection Mucosal Immunology, 2022-04-13;0(0):. 2022-04-13 [PMID: 35418673] (Mouse)
• E Iizasa, Y Chuma, T Uematsu, M Kubota, H Kawaguchi, M Umemura, K Toyonaga, H Kiyohara, I Yano, M Colonna, M Sugita, G Matsuzaki, S Yamasaki, H Yoshida, H Hara TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation Nature Communications, 2021-04-16;12(1):2299. 2021-04-16 [PMID: 33863908] (Mouse)
• W Zhou, Y Yang, C Mei, P Dong, S Mu, H Wu, Y Zhou, Y Zheng, F Guo, JQ Yang Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection Cells, 2019-10-16;8(10):. 2019-10-16 [PMID: 31623153] (Mouse)
• P Saha, BS Yeoh, X Xiao, RM Golonka, V Singh, Y Wang, M Vijay-Kuma PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium Mucosal Immunol, 2019-02-01;0(0):. 2019-02-01 [PMID: 30710097] (Mouse)
• ER? in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity J Immunol, 2016-05-13;0(0):. 2016-05-13 [PMID: 27183630] (Mouse)
• Brant F, Miranda A, Esper L, Rodrigues D, Kangussu L, Bonaventura D, Soriani F, Pinho V, Souza D, Rachid M, Weiss L, Tanowitz H, Teixeira M, Teixeira A, Machado F Role of the aryl hydrocarbon receptor in the immune response profile and development of pathology during Plasmodium berghei Anka infection. Infect Immun, 2014-05-12;82(8):3127-40. 2014-05-12 [PMID: 24818665] (Mouse)
• Miyauchi , Eiji, Ogita , Tasuku, Miyamoto , Junki, Kawamoto , Seiji, Morita , Hidetosh, Ohno , Hiroshi, Suzuki , Takuya, Tanabe , Soichi Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules. PLoS ONE, 2013-11-08;8(11):e79735. 2013-11-08 [PMID: 24255712] (Mouse)
• Solt L, Kamenecka T, Burris T LXR-mediated inhibition of CD4+ T helper cells. PLoS ONE, 2012-09-28;7(9):e46615. 2012-09-28 [PMID: 23029557] (Mouse)

FAQs for IL-17A/F Heterodimer (DY5390). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.