IL-17A/F Heterodimer Products

Description

Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by a subset of T helper cells that develops distinct from the Th1- and Th2- cell differentiation pathways. IL-17, also known as CTLA-8, stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGFB (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other proinflammatory cytokines. IL-17 (~32kDa) protein is produced and exists as a homo-dimer, has homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells.

Bioinformatics

Product By Gene ID	3605
Alternate Names	CTLA8 CTLA8cytotoxic T-lymphocyte-associated serine esterase 8 Cytotoxic T-lymphocyte-associated antigen 8 Cytotoxic T-Lymphocyte-Associated Protein 8 IL17 IL-17 IL-17A IL-17A/F Heterodimer interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) interleukin 17A interleukin-17A