Mouse ICAM-1/CD54 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse ICAM-1/CD54 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Icam1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse ICAM-1/CD54 DuoSet ELISA, 15 Plate

• BB2
• CD54 antigen
• CD54
• cell surface glycoprotein P3.58
• human rhinovirus receptor
• ICAM1
• ICAM-1
• intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
• intercellular adhesion molecule 1
• Major group rhinovirus receptor
• P3.58

Background

ICAM-1 (intercellular adhesion molecule-1), also known as CD54, is a transmembrane protein that is upregulated on endothelial and epithelial cells at sites of inflammation. It mediates the vascular adhesion and paracellular migration of leukocytes expressing activated LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also binds several non-integrin ligands including CD43/Sialophorin, Fibrinogen, Hyaluronan, rhinoviruses, and Plasmodium falciparum-infected erythrocytes. Soluble ICAM-1 promotes angiogenesis and serves an indicator of vascular endothelial cell activation or damage. Elevated levels of soluble ICAM-1 are associated with cardiovascular disease, type 2 diabetes, organ transplant dysfunction, oxidant stress, increased abdominal fat mass, hypertension, liver disease, certain malignancies, and cerebral malaria.

Publications for ICAM-1/CD54 (DY796)(9)

Publications using DY796

• Manandhar, S;Gaddam, RR;Chambers, S;Bhatia, M; Kupffer Cell Inactivation Alters Endothelial Cell Adhesion Molecules in Cecal Ligation and Puncture-Induced Sepsis Biomolecules 2024-01-09 [PMID: 38254684] (Mouse)
• Manandhar, S;Chambers, S;Miller, A;Ishii, I;Bhatia, M; Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells International journal of molecular sciences 2023-09-04 [PMID: 37686458] (Mouse, Transgenic Mouse)
• F Seidel, R Kleemann, W van Duyven, N van Trigt, N Keijzer, S van der Ko, C van Kooten, L Verschuren, A Menke, AJ Kiliaan, J Winter, TR Hughes, BP Morgan, F Baas, K Fluiter, MC Morrison Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice International Journal of Molecular Sciences, 2022-09-14;23(18):. 2022-09-14 [PMID: 36142647] (Mouse)
• L Huang, W Liang, K Zhou, RA Wassel, ZD Ridge, JX Ma, B Wang Therapeutic Effects of Fenofibrate Nano-Emulsion Eye Drops on Retinal Vascular Leakage and Neovascularization Biology, 2021-12-15;10(12):. 2021-12-15 [PMID: 34943243] (Mouse)
• G Cohen, P Chandran, RM Lorsung, LE Tomlinson, M Sundby, SR Burks, JA Frank The Impact of Focused Ultrasound in Two Tumor Models: Temporal Alterations in the Natural History on Tumor Microenvironment and Immune Cell Response Cancers (Basel), 2020-02-04;12(2):. 2020-02-04 [PMID: 32033171] (Mouse)
• A Leiva, S Contreras-, L Amigo, E Sepúlveda, M Boric, V Quiñones, D Busso, A Rigotti Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice PLoS ONE, 2017-09-14;12(9):e0184280. 2017-09-14 [PMID: 28910310] (Mouse)
• MJ Haley, G Mullard, KA Hollywood, GJ Cooper, WB Dunn, CB Lawrence Adipose tissue, metabolic and inflammatory responses to stroke are altered in obese mice Dis Model Mech, 2017-08-10;0(0):. 2017-08-10 [PMID: 28798136] (Mouse)
• LN Masi, AR Martins, AR Crisma, CL do Amaral, MR Davanso, TDA Serdan, RDC da Cunha d, MM Cruz, MIC Alonso-Val, RP Torres, J Mancini-Fi, JNB Pereira, MM da Silva R, EA Liberti, SM Hirabara, R Curi Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice Sci Rep, 2017-06-21;7(1):3937. 2017-06-21 [PMID: 28638152] (Mouse)
• Hegde A, Zhang H, Moochhala SM, Bhatia M Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. J. Leukoc. Biol., 2007-06-12;82(3):678-85. 2007-06-12 [PMID: 17565047] (Mouse)

Bioinformatics

• Gene Symbol: Icam1