Mouse Amphiregulin DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Amphiregulin DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Areg

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Amphiregulin DuoSet ELISA, 15 Plate

• Amphiregulin
• AR
• AREG
• AREGB
• Colorectum cell-derived growth factor
• CRDGF
• MGC13647
• schwannoma-derived growth factor
• SDGF

Background

Amphiregulin (AR) is an EGF family growth factor that is released as a soluble protein following proteolytic cleavage of its transmembrane precursor. Amphiregulin is expressed by numerous carcinoma cell lines and epithelial cells of the colon, stomach, breast, ovary and kidney. It acts through ErbB family of receptor to stimulate the proliferation of keratinocytes, mammary epithelial cells, fibroblasts, astrocytes and glial cells. Amphiregulin can also inhibit the growth of certain tumor cells.

Publications for Amphiregulin (DY989)(29)

Publications using DY989

• Cook, PC;Brown, SL;Houlder, EL;Furlong-Silva, J;Conn, DP;Colombo, SAP;Baker, S;Svedberg, FR;Howell, G;Bertuzzi, M;Boon, L;Konkel, JE;Thornton, CR;Allen, JE;MacDonald, AS; Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice Nature communications 2025-01-22 [PMID: 39843887] (Mouse)
• Ma, R;Prigge, AD;Ortiz Serrano, TP;Cheng, Y;Davis, JM;Lou, KF;Wood, WA;Do, HC;Ren, Z;Fulcer, MM;Lotesto, MJ;Singer, BD;Coates, BM;Ridge, KM; Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia Cell reports 2024-12-07 [PMID: 39645657] (Mouse)
• Walkenhorst, M;Sonner, JK;Meurs, N;Engler, JB;Bauer, S;Winschel, I;Woo, MS;Raich, L;Winkler, I;Vieira, V;Unger, L;Salinas, G;Lantz, O;Friese, MA;Willing, A; Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis Nature communications 2024-10-28 [PMID: 39468055] (Mouse)
• Zhao, R;Wang, Z;Wang, G;Geng, J;Wu, H;Liu, X;Bin, E;Sui, J;Dai, H;Tang, N; Sustained amphiregulin expression in intermediate alveolar stem cells drives progressive fibrosis Cell stem cell 2024-07-27 [PMID: 39096904] (Mouse)
• Raugh, A;Jing, Y;Bettini, ML;Bettini, M; The Amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes Research square 2023-08-03 [PMID: 37577652] (Mouse)
• A Amin, M Badenes, J Tüshaus, É de Carvalh, E Burbridge, P Faísca, K Trávní?kov, A Barros, S Carobbio, PM Domingos, A Vidal-Puig, LF Moita, S Maguire, K St?íšovský, FJ Ortega, JM Fernández-, SF Lichtentha, C Adrain Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis Molecular Metabolism, 2023-04-28;0(0):101731. 2023-04-28 [PMID: 37121509] (ELISA, Mouse)
• B Lee, SK Kim, YJ Shin, YH Son, JW Yang, SM Lee, YR Yang, KP Lee, KS Kwon Genome-wide analysis of a cellular exercise model based on electrical pulse stimulation Scientific Reports, 2022-12-08;12(1):21251. 2022-12-08 [PMID: 36481702] (Mouse)
• CR Morris, A Habibovic, CM Dustin, C Schiffers, MC Lin, JL Ather, YMW Janssen-He, ME Poynter, O Utermohlen, M Krönke, A van der Vl Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease Mucosal Immunology, 2022-06-02;0(0):. 2022-06-02 [PMID: 35654836] (Mouse)
• J Pohar, R O'Connor, B Manfroi, ME Behi, L Jouneau, P Boudinot, M Bunse, W Uckert, M Luka, M Ménager, R Liblau, SM Anderton, S Fillatreau Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using non-redundant immune mechanisms in mice European Journal of Immunology, 2022-05-27;0(0):. 2022-05-27 [PMID: 35579560] (Mouse)
• Lauren M. Buelow, Akihiko Hoji, Kiet Tat, Lindsay M. Schroeder-Carter, Daniela J. Carroll, Joan M. Cook-Mills Mechanisms for Alternaria alternata Function in the Skin During Induction of Peanut Allergy in Neonatal Mice With Skin Barrier Mutations Frontiers in Allergy 2021-09-06 [PMID: 35387035] (Mouse)
• A Ulu, A Burr, AJ Heires, J Pavlik, T Larsen, PA Perez, C Bravo, NV DiPatrizio, M Baack, DJ Romberger, TM Nordgren A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts: Role of DHA in repetitive organic dust exposure The Journal of nutritional biochemistry, 2021-06-12;0(0):108797. 2021-06-12 [PMID: 34126202] (Mouse)
• SS Son, S Hwang, JH Park, Y Ko, SI Yun, JH Lee, B Son, TR Kim, HO Park, EY Lee In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals Scientific Reports, 2021-01-26;11(1):2191. 2021-01-26 [PMID: 33500443] (Mouse)
• V Hosur, BE Low, D Li, GA Stafford, V Kohar, LD Shultz, MV Wiles Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation Genome Biol., 2020-07-09;21(1):168. 2020-07-09 [PMID: 32646486] (Mouse)
• AN Johnson, JR Harkema, AJ Nelson, JD Dickinson, J Kalil, MJ Duryee, GM Thiele, B Kumar, AB Singh, R Gaurav, SC Glover, Y Tang, DJ Romberger, T Kielian, JA Poole MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease Respir. Res., 2020-04-22;21(1):97. 2020-04-22 [PMID: 32321514] (Mouse)
• SP Kubli, C Bassi, C Roux, A Wakeham, C Göbl, W Zhou, SM Jafari, B Snow, L Jones, L Palomero, KL Thu, L Cassetta, D Soong, T Berger, P Ramachandr, SP Baniasadi, G Duncan, M Lindzen, Y Yarden, C Herranz, C Lazaro, MF Chu, J Haight, P Tinto, J Silvester, DW Cescon, A Petit, S Pettersson, JW Pollard, TW Mak, MA Pujana, P Cappello, C Gorrini AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer Proc. Natl. Acad. Sci. U.S.A., 2019-02-07;0(0):. 2019-02-07 [PMID: 30733286] (Mouse)
• W Dong, L Liu, Y Dou, M Xu, T Liu, S Wang, Y Zhang, B Deng, B Wang, H Cao Deoxycholic acid activates epidermal growth factor receptor and promotes intestinal carcinogenesis by ADAM17-dependent ligand release J. Cell. Mol. Med., 2018-06-29;0(0):. 2018-06-29 [PMID: 29956475] (Mouse)
• S Schmidt, N Schumacher, J Schwarz, S Tangermann, L Kenner, M Schlederer, M Sibilia, M Linder, A Altendorf-, T Knösel, ES Gruber, G Oberhuber, J Bolik, A Rehman, A Sinha, J Lokau, P Arnold, AS Cabron, F Zunke, C Becker-Pau, A Preaudet, P Nguyen, J Huynh, S Afshar-Ste, AL Chand, J Westermann, PJ Dempsey, C Garbers, D Schmidt-Ar, P Rosenstiel, T Putoczki, M Ernst, S Rose-John ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling J. Exp. Med., 2018-02-22;0(0):. 2018-02-22 [PMID: 29472497] (Mouse)
• V Hosur, BE Low, LD Shultz, MV Wiles Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis Biol Open, 2017-08-15;0(0):. 2017-08-15 [PMID: 28655741] (Mouse)
• DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma JCI Insight, 2016-11-03;1(18):e88811. 2016-11-03 [PMID: 27812543] (Mouse)
• ADAM17 substrate release in proximal tubule drives kidney fibrosis JCI Insight, 2016-08-18;1(13):. 2016-08-18 [PMID: 27642633] (Mouse)
• Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females PLoS Pathog, 2016-09-15;12(9):e1005840. 2016-09-15 [PMID: 27631986] (Mouse)
• Zhang C, Spevak W, Zhang Y, Burton E, Ma Y, Habets G, Zhang J, Lin J, Ewing T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, Fong D, Nguyen H, Shi S, Womack P, Nespi M, Shellooe R, Carias H, Powell B, Light E, Sanftner L, Walters J, Tsai J, West B, Visor G, Rezaei H, Lin P, Nolop K, Ibrahim P, Hirth P, Bollag G RAF inhibitors that evade paradoxical MAPK pathway activation. Nature, 2015-10-14;526(7574):583-6. 2015-10-14 [PMID: 26466569] (Mouse)
• Subramaniam R, Hillberry Z, Chen H, Feng Y, Fletcher K, Neuenschwander P, Shams H Delivery of GM-CSF to Protect against Influenza Pneumonia. PLoS ONE, 2015-04-29;10(4):e0124593. 2015-04-29 [PMID: 25923215] (Mouse)
• Furuya Y, Roberts S, Hurteau G, Sanfilippo A, Racine R, Metzger D Asthma increases susceptibility to heterologous but not homologous secondary influenza. J Virol, 2014-06-04;88(16):9166-81. 2014-06-04 [PMID: 24899197] (Mouse)
• Turner , Jan-Eric, Morrison , Peter J, Wilhelm , Christop, Wilson , Mark, Ahlfors , Helena, Renauld , Jean-Chr, Panzer , Ulf, Helmby , Helena, Stockinger , Brigitta IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med, 2013-11-18;210(13):2951-65. 2013-11-18 [PMID: 24249111] (Mouse)
• Blok D, van der Sluijs K, Florquin S, de Boer O, van 't Veer C, de Vos A, van der Poll T Limited anti-inflammatory role for interleukin-1 receptor like 1 (ST2) in the host response to murine postinfluenza pneumococcal pneumonia. PLoS ONE, 2013-03-06;8(3):e58191. 2013-03-06 [PMID: 23483993] (Mouse)
• Zhou Y, Lee J, Lee C, Cho W, Kang M, Koff J, Yoon P, Chae J, Park H, Elias J, Lee C Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-beta-induced pulmonary fibrosis. J Biol Chem, 2012-10-19;287(50):41991-2000. 2012-10-19 [PMID: 23086930] (Mouse)
• Monticelli LA, Sonnenberg GF, Abt MC Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol., 2011-11-01;12(11):1045-54. 2011-11-01 [PMID: 21946417] (Mouse)
• Murthy A, Defamie V, Smookler DS Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J. Clin. Invest., 2010-07-12;120(8):2731-44. 2010-07-12 [PMID: 20628198] (Mouse)

FAQs for Amphiregulin (DY989). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Areg