Mouse Adiponectin/Acrp30 Quantikine ELISA Kit

Changes in steroid hormone levels and adipokine levels in peripheral blood. (a) Testosterone. (b) Estradiol. (c) Corticosterone. (d) DHEA. (e) Leptin. (f) Adiponectin. For all groups, n = 8. Values are expressed as mean ± standard error. *P < 0.05, significantly different from the 3moR group. Image collected and cropped by CiteAb from the following open publication (//www.nature.com/articles/s41598-017-12358-8), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse Adiponectin/Acrp30 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse Adiponectin Immunoassay is a 4.5 hour solid phase ELISA designed to measure full-length mouse Adiponectin levels in cell culture supernates, tissue homogenates, serum, and plasma. It contains NS0-expressed recombinant mouse Adiponectin and antibodies raised against the recombinant protein. Results obtained for naturally occurring mouse Adiponectin showed linear curves th...at were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values of natural mouse Adiponectin.
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• Specificity: Natural and recombinant full-length mouse Adiponectin. This assay only recognizes full-length mouse Adiponectin. It does not recognize mouse gAdiponectin.
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Adipoq

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Adiponectin/Acrp30 Quantikine ELISA Kit

• ACDC
• Acrp30
• ACRP30ADPN
• adipocyte, C1Q and collagen domain containing
• Adiponectin
• adiponectin, C1Q and collagen domain containing
• AdipoQ
• ADIPQTL1
• ApM1
• apM-1
• APM1APM-1
• C1q and collagen domain-containing protein
• GBP28
• GBP28apM1
• Gelatin-binding protein

Background

Adiponectin (also known as Adipocyte complement-related protein of 30 kDa, Acrp30) is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. It promotes adipocyte differentiation, fatty acid catabolism, and insulin sensitivity and is negatively correlated with obesity, type 2 diabetes, and atherogenesis. Adiponectin associates into 70 kDa noncovalently-linked trimers that are disulfide-linked into medium molecular weight hexamers and then into >300 kDa high molecular weight oligomers.

&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Adiponectin/Acrp30 (MRP300)(101)

Publications using MRP300

• Kim, MH;Kim, SJ;Park, WJ;Lee, DH;Kim, KK; GR113808, a serotonin receptor 4 antagonist, prevents high-fat-diet-induced obesity, fatty liver formation, and insulin resistance in C57BL/6J mice BMC pharmacology & toxicology 2024-10-11 [PMID: 39394150] (Mouse)
• Abdollahi, A;Szramowski, M;Tomoo, K;Henderson, GC; Metabolic responses to albumin deficiency differ distinctly between partial and full ablation of albumin expression in mice Lipids in health and disease 2024-08-09 [PMID: 39123208] (Mouse)
• Steiner, BM;Benvie, AM;Lee, D;Jiang, Y;Berry, DC; Cxcr4 regulates a pool of adipocyte progenitors and contributes to adiposity in a sex-dependent manner Nature communications 2024-08-05 [PMID: 39103342] (Transgenic Mouse)
• Rathaus, M;Azem, L;Livne, R;Ron, S;Ron, I;Hadar, R;Efroni, G;Amir, A;Braun, T;Haberman, Y;Tirosh, A; Long-term Metabolic Effects of Non-Nutritive Sweeteners Molecular metabolism 2024-07-06 [PMID: 38977130] (Mouse)
• Yeh, CL;Wu, JM;Chen, KY;Wu, MH;Yang, PJ;Lee, PC;Chen, PD;Kuo, TC;Yeh, SL;Lin, MT; Calcitriol attenuates poly(I:C)-induced lung injury in obese mice via modulating toll-like receptor 3- and renin-angiotensin system-associated signal pathways International immunopharmacology 2024-01-19 [PMID: 38246004] (Mouse)
• Tee, JH;Vijayakumar, U;Shanmugasundaram, M;Lam, TYW;Liao, W;Yang, Y;Wong, WSF;Ge, R; Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice Respiratory research 2023-11-06 [PMID: 37932719] (Mouse, Transgenic Mouse)
• Kabir, T;Yoshiba, H;Agista, AZ;Sultana, H;Ohsaki, Y;Yeh, CL;Hirakawa, R;Tani, H;Ikuta, T;Nochi, T;Yang, SC;Shirakawa, H; Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model Nutrients 2023-09-06 [PMID: 37764672] (Mouse)
• C Lee, S Kim, B Kim, WH Holzapfel, CK Hyun Disturbance of lipid metabolism in germ-free mice transplanted with gut microbiota of DSS-induced colitis mice PLoS ONE, 2023-02-03;18(2):e0280850. 2023-02-03 [PMID: 36735734] (Mouse)
• T Hirabayash, M Kawaguchi, S Harada, M Mouri, R Takamiya, Y Miki, H Sato, Y Taketomi, K Yokoyama, T Kobayashi, SM Tokuoka, Y Kita, E Yoda, S Hara, K Mikami, Y Nishito, N Kikuchi, R Nakata, M Kaneko, H Kiyonari, K Kasahara, T Aiba, K Ikeda, T Soga, M Kurano, Y Yatomi, M Murakami Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups Cell Reports, 2023-01-30;42(2):111940. 2023-01-30 [PMID: 36719796] (Mouse)
• S Raia, A Conti, A Zanardi, B Ferrini, GM Scotti, E Gilberti, G De Palma, S David, M Alessio Ceruloplasmin-Deficient Mice Show Dysregulation of Lipid Metabolism in Liver and Adipose Tissue Reduced by a Protein Replacement International Journal of Molecular Sciences, 2023-01-06;24(2):. 2023-01-06 [PMID: 36674661] (Mouse)
• MK Hong, Y Han, HJ Park, MR Shin, SS Roh, EY Kwon The Synergistic Action of Metformin and Glycyrrhiza uralensis Fischer Extract Alleviates Metabolic Disorders in Mice with Diet-Induced Obesity International Journal of Molecular Sciences, 2023-01-04;24(2):. 2023-01-04 [PMID: 36674447] (Mouse)
• SR Giri, B Bhoi, C Trivedi, A Rath, R Rathod, A Sharma, R Ranvir, S Kadam, K Ingale, H Patel, A Nyska, MR Jain Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet BMC Cancer, 2023-01-17;23(1):59. 2023-01-17 [PMID: 36650455] (Mouse)
• N Cuesta, S Fernández-, C Punzón, C Moreno, B Barrocal, V Sreeramkum, M Desco, M Fresno Opposing Actions of TLR2 and TLR4 in Adipocyte Differentiation and Mature-Onset Obesity International Journal of Molecular Sciences, 2022-12-10;23(24):. 2022-12-10 [PMID: 36555322] (Mouse)
• S Ahn, M Ahn, S Park, S An, IG Park, SY Hwang, J Gong, S Oh, SH Jin, HJ Kim, JH Cheong, Y Byun, M Noh Discovery of PPARgamma and glucocorticoid receptor dual agonists to promote the adiponectin and leptin biosynthesis in human bone marrow mesenchymal stem cells European Journal of Medicinal Chemistry, 2022-11-10;245(0):114927. 2022-11-10 [PMID: 36379105] (Mouse)
• DK Lee, T Kim, J Byeon, M Park, S Kim, J Kim, S Choi, G Lee, C Park, KW Lee, YJ Kwon, JH Lee, YG Kwon, YM Kim REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-kappaB activation Nature Communications, 2022-10-22;13(1):6303. 2022-10-22 [PMID: 36272977] (Mouse)
• H Shi, RA Prough, CJ McClain, M Song Different Types of Dietary Fat and Fructose Interactions Result in Distinct Metabolic Phenotypes in Male Mice The Journal of nutritional biochemistry, 2022-10-19;0(0):109189. 2022-10-19 [PMID: 36272691] (Mouse)
• A Aflatounia, VR Paris, D Richani, MC Edwards, BJ Cochran, WL Ledger, RB Gilchrist, MJ Bertoldo, LE Wu, KA Walters Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation Molecular Metabolism, 2022-09-09;65(0):101583. 2022-09-09 [PMID: 36096453] (Mouse)
• JW Kim, YM Yang, EY Kwon, JY Choi Novel Plant Extract Ameliorates Metabolic Disorder through Activation of Brown Adipose Tissue in High-Fat Diet-Induced Obese Mice International Journal of Molecular Sciences, 2022-08-18;23(16):. 2022-08-18 [PMID: 36012561] (Mouse)
• N Melnikov, Y Kamari, M Kandel-Kfi, I Barshack, A Ben-Amotz, D Harats, A Shaish, A Harari beta-Carotene from the Alga Dunaliella bardawil Decreases Gene Expression of Adipose Tissue Macrophage Recruitment Markers and Plasma Lipid Concentrations in Mice Fed a High-Fat Diet Marine Drugs, 2022-06-29;20(7):. 2022-06-29 [PMID: 35877726] (Mouse)
• YY Sung, SH Kim, DS Kim Combined Phyllostachys pubescens and Scutellaria baicalensis Prevent High-Fat Diet-Induced Obesity via Upregulating Thermogenesis and Energy Expenditure by UCP1 in Male C57BL/6J Mice Nutrients, 2022-01-19;14(3):. 2022-01-19 [PMID: 35276805] (Mouse)
• SK Gunasekar, L Xie, A Kumar, J Hong, PR Chheda, C Kang, DM Kern, C My-Ta, J Maurer, J Heebink, EE Gerber, WJ Grzesik, M Elliot-Hud, Y Zhang, P Key, CA Kulkarni, JW Beals, GI Smith, I Samuel, JK Smith, P Nau, Y Imai, RD Sheldon, EB Taylor, DJ Lerner, AW Norris, S Klein, SG Brohawn, R Kerns, R Sah Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes Nature Communications, 2022-02-10;13(1):784. 2022-02-10 [PMID: 35145074] (Mouse)
• HMA Javaid, NE Sahar, DL ZhuGe, JY Huh Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like Cells, 2021-12-09;10(12):. 2021-12-09 [PMID: 34943988] (Mouse)
• HL Black, R Livingston, CC Mastick, M Al Tobi, H Taylor, A Geiser, L Stirrat, D Kioumourtz, JR Petrie, JG Boyle, NJ Bryant, GW Gould Knockout of Syntaxin-4 in 3T3-L1 adipocytes reveals new insight into GLUT4 trafficking and adiponectin secretion Journal of Cell Science, 2022-01-10;0(0):. 2022-01-10 [PMID: 34859814] (Mouse)
• K Kurup, SN Mann, J Jackson, S Matyi, M Ranjo-Bish, WM Freeman, MB Stout, A Richardson, A Unnikrishn Litter expansion alters metabolic homeostasis in a sex specific manner PLoS ONE, 2021-09-29;16(9):e0237199. 2021-09-29 [PMID: 34587168] (Mouse)
• E Lana-Elola, H Cater, S Watson-Sca, S Greenaway, J Müller-Win, D Gibbins, M Nemes, A Slender, T Hough, P Keskivali-, CL Scudamore, E Herbert, GT Banks, H Mobbs, T Canonica, J Tosh, S Noy, M Llorian, PM Nolan, JL Griffin, M Good, M Simon, AM Mallon, S Wells, EMC Fisher, VLJ Tybulewicz Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes Disease Models & Mechanisms, 2021-10-15;14(10):. 2021-10-15 [PMID: 34477842] (Mouse)
• P Dhanraj, MB van Heerde, MS Pepper, MA Ambele Sexual Dimorphism in Changes That Occur in Tissues, Organs and Plasma during the Early Stages of Obesity Development Biology, 2021-07-28;10(8):. 2021-07-28 [PMID: 34439950] (Mouse)
• W Miao, L Jiang, F Xu, J Lyu, X Jiang, M He, Y Liu, T Yang, RK Leak, RA Stetler, J Chen, X Hu Adiponectin ameliorates hypoperfusive cognitive deficits by boosting a neuroprotective microglial response Progress in neurobiology, 2021-07-29;205(0):102125. 2021-07-29 [PMID: 34333040] (Mouse)
• J Gao, J Fan, Z Meng, R Wang, C Liu, J Liu, B Liang, J Wang, Y Xie, J Zhao, R Guo, J Zhao, X Ma, X Jiao, J Cao, Y Wang Nicotine aggravates vascular adiponectin resistance via ubiquitin-mediated adiponectin receptor degradation in diabetic Apolipoprotein E knockout mouse Cell Death & Disease, 2021-05-18;12(6):508. 2021-05-18 [PMID: 34006831] (Mouse)
• JD Plummer, SD Postnikoff, JK Tyler, JE Johnson Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice Elife, 2021-03-30;10(0):. 2021-03-30 [PMID: 33783357] (Mouse)
• YS Kim, HH Cho, DI Cho, HY Jeong, SY Lim, JH Jun, MR Kim, BG Kang, M Cho, HJ Kang, WS Kang, GT Oh, Y Ahn The adipokine Retnla deficiency increases responsiveness to cardiac repair through adiponectin-rich bone marrow cells Cell Death & Disease, 2021-03-22;12(4):307. 2021-03-22 [PMID: 33753732] (Mouse)
• Z Zhang, X Chen, YJ Loh, X Yang, C Zhang The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice Bmc Biology, 2021-03-19;19(1):51. 2021-03-19 [PMID: 33740961] (Mouse)
• M Kalisz, M Chmielowsk, L Marty?ska, A Doma?ska, W Bik, A Litwiniuk All-trans-retinoic acid ameliorates atherosclerosis, promotes perivascular adipose tissue browning, and increases adiponectin production in Apo-E mice Scientific Reports, 2021-02-24;11(1):4451. 2021-02-24 [PMID: 33627760] (Mouse)
• T Kawamura, H Tanaka, R Tachibana, K Yoshikawa, S Maki, K Toriyabe, H Takeuchi, S Katsuragi, K Tanaka, T Ikeda Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring Scientific Reports, 2021-01-13;11(1):1186. 2021-01-13 [PMID: 33441894] (Mouse)
• F Juszczak, M Vlassembro, O Botton, T Zwakhals, M Decarnoncl, A Tassin, N Caron, AE Declèves Delayed Exercise Training Improves Obesity-Induced Chronic Kidney Disease by Activating AMPK Pathway in High-Fat Diet-Fed Mice International Journal of Molecular Sciences, 2020-12-31;22(1):. 2020-12-31 [PMID: 33396267] (Mouse)
• JG Wagner, CE Barkauskas, A Vose, RP Lewandowsk, JR Harkema, RM Tighe Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains Environmental health perspectives, 2020-11-30;128(11):117009. 2020-11-30 [PMID: 33253011] (Mouse)
• J Song, J Kim, HJ Park, H Kim Anti-Obesity Effects of a Prunus persica and Nelumbo nucifera Mixture in Mice Fed a High-Fat Diet Nutrients, 2020-11-04;12(11):. 2020-11-04 [PMID: 33158191] (Mouse)
• V Saraswathi, N Kumar, T Gopal, S Bhatt, W Ai, C Ma, GA Talmon, C Desouza Lauric Acid versus Palmitic Acid: Effects on Adipose Tissue Inflammation, Insulin Resistance, and Non-Alcoholic Fatty Liver Disease in Obesity Biology (Basel), 2020-10-22;9(11):. 2020-10-22 [PMID: 33105887] (Mouse)
• V Rodriguez, SM Solon-Biet, AM Senior, MC Edwards, R Desai, N Tedla, MJ Cox, WL Ledger, RB Gilchrist, SJ Simpson, DJ Handelsman, KA Walters Defining the impact of dietary macronutrient balance on PCOS traits Nat Commun, 2020-10-16;11(1):5262. 2020-10-16 [PMID: 33067453] (Mouse)
• J Wang, C Ortiz, L Fontenot, R Mukhopadhy, Y Xie, IKM Law, DQ Shih, SA Mattai, Z Li, HW Koon Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice Sci Rep, 2020-07-30;10(1):12785. 2020-07-30 [PMID: 32733043] (Mouse)
• J Varghese, JV James, R Anand, M Narayanasa, G Rebekah, B Ramakrishn, AJ Nellickal, M Jacob Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet J. Nutr. Biochem., 2020-06-02;84(0):108441. 2020-06-02 [PMID: 32629238] (Mouse)
• RS Bergmans, M Nikodemova, VJ Stull, A Rapp, KMC Malecki Comparison of cricket diet with peanut-based and milk-based diets in the recovery from protein malnutrition in mice and the impact on growth, metabolism and immune function PLoS ONE, 2020-06-11;15(6):e0234559. 2020-06-11 [PMID: 32525953] (Mouse)
• T Kroon, M Harms, S Maurer, L Bonnet, I Alexanders, A Lindblom, A Ahnmark, D Nilsson, P Gennemark, G O'Mahony, V Osinski, C McNamara, J Boucher PPAR&amp;gamma and PPAR&amp;alpha synergize to induce robust browning of white fat in�vivo Mol Metab, 2020-02-18;36(0):100964. 2020-02-18 [PMID: 32248079] (Mouse)
• S Dey, Z Cui, O Gavrilova, X Zhang, M Gassmann, CT Noguchi Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation JCI Insight, 2020-03-12;5(5):. 2020-03-12 [PMID: 32078583] (Mouse)
• JM Hoffmann, JR Grünberg, A Hammarsted, T Kroon, TU Greiner, S Maurer, I Elias, V Palsdottir, F Bosch, J Boucher, S Hedjazifar, U Smith BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice Mol Metab, 2019-12-17;32(0):15-26. 2019-12-17 [PMID: 32029225] (Mouse)
• AA Kanhai, H Bange, L Verburg, KL Dijkstra, LS Price, DJM Peters, WN Leonhard Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective Sci Rep, 2020-02-03;10(1):1672. 2020-02-03 [PMID: 32015419] (Mouse)
• SW Görgens, K Jahn-Hofma, D Bangari, S Cummings, C Metz-Weidm, U Schwahn, P Wohlfart, M Schäfer, M Bielohuby A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice PLoS ONE, 2019-12-03;14(12):e0225835. 2019-12-03 [PMID: 31794591] (Mouse)
• E Galli, J Rossi, T Neumann, JO Andressoo, S Drinda, P Lindholm Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice Sci Rep, 2019-10-04;9(1):14318. 2019-10-04 [PMID: 31586115] (Mouse)
• S Gooding, SWZ Olechnowic, EV Morris, AE Armitage, J Arezes, J Frost, E Repapi, JR Edwards, N Ashley, C Waugh, N Gray, E Martinez-H, PJ Lim, SR Pasricha, H Knowles, AJ Mead, K Ramasamy, H Drakesmith, CM Edwards Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease Nat Commun, 2019-10-04;10(1):4533. 2019-10-04 [PMID: 31586071] (Mouse)
• M Pierard, A Tassin, S Conotte, K Zouaoui Bo, A Legrand Sustained Intermittent Hypoxemia Induces Adiponectin Oligomers Redistribution and a Tissue-Specific Modulation of Adiponectin Receptor in Mice Front Physiol, 2019-02-08;10(0):68. 2019-02-08 [PMID: 30800074] (Mouse)
• A Bodur, ? ?nce, C Kahraman, ? Abidin, S Aydin-Abid, A Alver Chronically reduced BDNF levels increase oxidative stress in epididymal, but not subcutaneous, adipose tissue following high sucrose and high fat diets fed mice Arch. Biochem. Biophys., 2019-02-21;0(0):. 2019-02-21 [PMID: 30797748] (Mouse)
• CA Gaulke, J Rolshoven, CP Wong, LG Hudson, E Ho, TJ Sharpton Marginal Zinc Deficiency and Environmentally Relevant Concentrations of Arsenic Elicit Combined Effects on the Gut Microbiome mSphere, 2018-12-05;3(6):. 2018-12-05 [PMID: 30518676] (Mouse)
• MD Li, NB Vera, Y Yang, B Zhang, W Ni, E Ziso-Qejva, S Ding, K Zhang, R Yin, S Wang, X Zhou, EX Fang, T Xu, DM Erion, X Yang Adipocyte OGT governs diet-induced hyperphagia and obesity Nat Commun, 2018-11-30;9(1):5103. 2018-11-30 [PMID: 30504766] (Mouse)
• L Zhao, Y Yamaguchi, WJ Shen, J Morser, LLK Leung Dynamic and tissue-specific proteolytic processing of chemerin in obese mice PLoS ONE, 2018-08-30;13(8):e0202780. 2018-08-30 [PMID: 30161155] (Mouse)
• MA Lopes, F Oliveira F, F Henriques, SB Peres, ML Batista LLC tumor cells-derivated factors reduces adipogenesis in co-culture system Heliyon, 2018-07-30;4(7):e00708. 2018-07-30 [PMID: 30094378] (Mouse)
• F Pan, L Zhang, M Li, Y Hu, B Zeng, H Yuan, L Zhao, C Zhang Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice Microbiome, 2018-03-21;6(1):54. 2018-03-21 [PMID: 29562943] (Mouse)
• S Nepali, DK Kim, HY Lee, HH Ki, BR Kim, SW Hwang, M Park, DK Kim, YM Lee Euphorbia supina extract results in inhibition of high?fat?diet?induced obesity in mice Int. J. Mol. Med., 2018-02-16;0(0):. 2018-02-16 [PMID: 29484428] (ELISA Capture, Mouse)
• X Yuan, K Tsujimoto, K Hashimoto, K Kawahori, N Hanzawa, M Hamaguchi, T Seki, M Nawa, T Ehara, Y Kitamura, I Hatada, M Konishi, N Itoh, Y Nakagawa, H Shimano, T Takai-Igar, Y Kamei, Y Ogawa Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood Nat Commun, 2018-02-12;9(1):636. 2018-02-12 [PMID: 29434210] (Mouse)
• Y Takahashi, R Watanabe, Y Sato, N Ozawa, M Kojima, K Watanabe-K, R Shirai, K Sato, T Hirano, T Watanabe Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis Metab. Clin. Exp., 2018-02-02;0(0):. 2018-02-02 [PMID: 29410350] (Mouse)
• B Xia, GH Cai, H Yang, SP Wang, GA Mitchell, JW Wu Adipose Tissue Deficiency of Hormone-Sensitive Lipase Causes Fatty Liver in Mice PLoS Genet., 2017-12-12;13(12):e1007110. 2017-12-12 [PMID: 29232702] (Mouse)
• L Piao, G Zhao, E Zhu, A Inoue, R Shibata, Y Lei, L Hu, C Yu, G Yang, H Wu, W Xu, K Okumura, N Ouchi, T Murohara, M Kuzuya, XW Cheng Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis J Am Heart Assoc, 2017-09-28;6(10):. 2017-09-28 [PMID: 28963101] (Mouse, Rat)
• S Komine, K Akiyama, E Warabi, S Oh, K Kuga, K Ishige, S Togashi, T Yanagawa, J Shoda Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis Sci Rep, 2017-09-20;7(1):11977. 2017-09-20 [PMID: 28931917] (Mouse)
• J Lee, J Choi, ES Selen Alpe, L Zhao, T Hartung, S Scafidi, RC Riddle, MJ Wolfgang Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance Cell Rep, 2017-07-18;20(3):655-667. 2017-07-18 [PMID: 28723568] (Mouse)
• Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype Mol Metab, 2017-05-06;6(7):725-736. 2017-05-06 [PMID: 28702328] (Mouse)
• S Danturti, KS Keslar, LR Steinhoff, R Fan, N Dvorina, A Valujskikh, RL Fairchild, WM Baldwin CD4+ T lymphocytes produce adiponectin in response to transplants JCI Insight, 2017-06-15;2(12):. 2017-06-15 [PMID: 28614792] (Mouse)
• AS Caldwell, MC Edwards, R Desai, M Jimenez, RB Gilchrist, DJ Handelsman, KA Walters Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome Proc. Natl. Acad. Sci. U.S.A, 2017-03-20;0(0):. 2017-03-20 [PMID: 28320971] (Mouse)
• N Fujii, T Narita, N Okita, M Kobayashi, Y Furuta, Y Chujo, M Sakai, A Yamada, K Takeda, T Konishi, Y Sudo, I Shimokawa, Y Higami Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction Aging Cell, 2017-03-03;0(0):. 2017-03-03 [PMID: 28256090] (Mouse)
• John R. Grünberg, Jenny M. Hoffmann, Shahram Hedjazifar, Annika Nerstedt, Lachmi Jenndahl, Johannes Elvin et al. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance Scientific Reports 2017-02-27 [PMID: 28240264] (Mouse)
• Ingrid C Rulifson In vitro and in vivo analyses reveal profound effects of fibroblast growth factor 16 as a metabolic regulator J. Biol. Chem, 2016-12-23;0(0):. 2016-12-23 [PMID: 28011645] (Mouse)
• Mouse P2Y4 nucleotide receptor is a negative regulator of cardiac adipose-derived stem cell differentiation and cardiac fat formation Stem Cells Dev., 2016-12-23;0(0):. 2016-12-23 [PMID: 27855539] (Mouse)
• Dietary ?-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice Sci Rep, 2016-05-25;6(0):26826. 2016-05-25 [PMID: 27220557] (Mouse)
• Lytle K, Jump D Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible? PLoS ONE, 2016-01-13;11(1):e0146942. 2016-01-13 [PMID: 26761430] (Mouse)
• Sasaki Y, Ohta M, Desai D, Figueiredo J, Whelan M, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik A, Inoue K, Mizuno K, Aikawa M Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance. PLoS ONE, 2015-07-01;10(7):e0131176. 2015-07-01 [PMID: 26132105] (Mouse)
• Scoditti E, Massaro M, Carluccio M, Pellegrino M, Wabitsch M, Calabriso N, Storelli C, De Caterina R Additive regulation of adiponectin expression by the mediterranean diet olive oil components oleic Acid and hydroxytyrosol in human adipocytes. PLoS ONE, 2015-06-01;10(6):e0128218. 2015-06-01 [PMID: 26030149] (Mouse)
• Zhao L, Kang I, Fang X, Wang W, Lee M, Hollins R, Marshall M, Chung S Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin resistance by inhibiting adipose inflammation and M1 macrophage recruitment. Int J Obes (Lond), 2014-07-21;39(3):438-46. 2014-07-21 [PMID: 25042861] (Mouse)
• Sajan M, Ivey R, Lee M, Mastorides S, Jurczak M, Samuels V, Shulman G, Braun U, Leitges M, Farese R PKClambda haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Mol Endocrinol, 2014-05-30;28(7):1097-107. 2014-05-30 [PMID: 24877563] (Mouse)
• Makki K, Taront S, Molendi-Coste O, Bouchaert E, Neve B, Eury E, Lobbens S, Labalette M, Duez H, Staels B, Dombrowicz D, Froguel P, Wolowczuk I Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice. PLoS ONE, 2014-04-07;9(4):e92684. 2014-04-07 [PMID: 24710396] (Mouse)
• de Boer A, Monk J, Robinson L Docosahexaenoic acid decreases pro-inflammatory mediators in an in vitro murine adipocyte macrophage co-culture model. PLoS ONE, 2014-01-20;9(1):e85037. 2014-01-20 [PMID: 24465472] (Mouse)
• Rao X, Zhong J, Xu X, Jordan B, Maurya S, Braunstein Z, Wang T, Huang W, Aggarwal S, Periasamy M, Rajagopalan S, Mehta K, Sun Q Exercise protects against diet-induced insulin resistance through downregulation of protein kinase Cbeta in mice. PLoS ONE, 2013-12-09;8(12):e81364. 2013-12-09 [PMID: 24349059] (Mouse)
• Paschos , Georgios, Ibrahim , Salam, Song , Wen-Lian, Kunieda , Takeshig, Grant , Gregory, Reyes , Teresa M, Bradfield , Christop, Vaughan , Cheryl H, Eiden , Michael, Masoodi , Mojgan, Griffin , Julian L, Wang , Fenfen, Lawson , John A, Fitzgerald , Garret A Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med, 2012-11-11;18(12):1768-77. 2012-11-11 [PMID: 23142819] (Mouse)
• Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice. Mol. Cell. Endocrinol., 2012-03-28;358(1):127-34. 2012-03-28 [PMID: 22476082] (Mouse)
• Chang ML, Yeh HC, Tsou YK HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration. Obesity (Silver Spring), 2012-02-23;20(7):1474-80. 2012-02-23 [PMID: 22421894] (Mouse)
• Ernst MC, Haidl ID, Zúñiga LA, Dranse HJ, Rourke JL, Zabel BA, Butcher EC, Sinal CJ Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance. Endocrinology, 2011-12-20;153(2):672-82. 2011-12-20 [PMID: 22186410] (Mouse)
• Floryk D, Kurosaka S, Tanimoto R, Yang G, Goltsov A, Park S, Thompson TC Castration-induced changes in mouse epididymal white adipose tissue. Mol. Cell. Endocrinol., 2011-07-12;345(1):58-67. 2011-07-12 [PMID: 21782885] (Mouse)
• De Lorenzo M, Baljinnyam E, Vatner D, Abarzua P, Vatner S, Rabson A Caloric restriction reduces growth of mammary tumors and metastases. Carcinogenesis, 2011-06-10;32(9):1381-7. 2011-06-10 [PMID: 21665891] (Mouse)
• Sato H, Isogai Y, Masuda S Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. J. Biol. Chem., 2011-01-25;286(13):11632-48. 2011-01-25 [PMID: 21266581] (Mouse)
• Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Saemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Diabetes, 2010-01-27;59(4):935-46. 2010-01-27 [PMID: 20107108] (Mouse)
• Zhu M, Hug C, Kasahara DI Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. Am. J. Respir. Cell Mol. Biol., 2009-11-13;43(4):487-97. 2009-11-13 [PMID: 19915153] (Mouse)
• Sasaki Y, Suzuki W, Shimada T, Iizuka S, Nakamura S, Nagata M, Fujimoto M, Tsuneyama K, Hokao R, Miyamoto K, Aburada M Dose dependent development of diabetes mellitus and non-alcoholic steatohepatitis in monosodium glutamate-induced obese mice. Life Sci., 2009-08-13;85(13):490-8. 2009-08-13 [PMID: 19683013] (Mouse)
• Zhao W, Thacker SG, Hodgin JB, Zhang H, Wang JH, Park JL, Randolph A, Somers EC, Pennathur S, Kretzler M, Brosius FC, Kaplan MJ The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine lupus. J. Immunol., 2009-07-20;183(4):2729-40. 2009-07-20 [PMID: 19620300] (Mouse)
• Hyvarinen K, Tuomainen AM, Laitinen S, Bykov IL, Tormakangas L, Lindros K, Käkelä R, Alfthan G, Salminen I, Jauhiainen M, Kovanen PT, Leinonen M, Saikku P, Pussinen PJ Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice. Infect. Immun., 2009-05-18;77(8):3442-9. 2009-05-18 [PMID: 19451238] (Mouse)
• Wu HS, Zhu DF, Zhou CX, Feng CR, Lou YJ, Yang B, He QJ Insulin sensitizing activity of ethyl acetate fraction of Acorus calamus L. in vitro and in vivo. J Ethnopharmacol, 2009-03-20;123(2):288-92. 2009-03-20 [PMID: 19429374] (Mouse)
• Zhang H, Matsuda H, Yamashita C, Nakamura S, Yoshikawa M Hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii as a new type of anti-diabetic compound. Eur. J. Pharmacol., 2009-01-17;606(1):255-61. 2009-01-17 [PMID: 19374876] (Mouse)
• Kuda O, Jelenik T, Jilkova Z, Flachs P, Rossmeisl M, Hensler M, Kazdova L, Ogston N, Baranowski M, Gorski J, Janovska P, Kus V, Polak J, Mohamed-Ali V, Burcelin R, Cinti S, Bryhn M, Kopecky J n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet. Diabetologia, 2009-03-11;52(5):941-51. 2009-03-11 [PMID: 19277604] (Mouse)
• Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. J. Clin. Invest., 2008-12-08;119(1):110-24. 2008-12-08 [PMID: 19065047] (Mouse)
• Pini M, Gove ME, Sennello JA, van Baal JW, Chan L, Fantuzzi G Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice. Endocrinology, 2008-05-01;149(8):4080-5. 2008-05-01 [PMID: 18450950] (Mouse)
• Lee MJ, Lin H, Liu CW, Wu MH, Liao WJ, Chang HH, Ku HC, Chien YS, Ding WH, Kao YH Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways. Am. J. Physiol., Cell Physiol., 2008-04-16;294(6):C1542-51. 2008-04-16 [PMID: 18417718] (Mouse)
• Jang EH, Moon JS, Ko JH, Ahn CW, Lee HH, Shin JK, Park CS, Kang JH Novel black soy peptides with antiobesity effects: activation of leptin-like signaling and AMP-activated protein kinase. Int J Obes (Lond), 2008-04-15;32(7):1161-70. 2008-04-15 [PMID: 18414417] (Mouse)
• Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth HE, Dreano M, De Vos R, Roskams T, Trautwein C Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. Gut, 2008-05-01;57(5):655-63. 2008-05-01 [PMID: 18408102] (Mouse)
• Kang JH, Kim CS, Han IS, Kawada T, Yu R Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Lett., 2007-08-14;581(23):4389-96. 2007-08-14 [PMID: 17719033] (Mouse)
• Kanatani Y, Usui I, Ishizuka K, Bukhari A, Fujisaka S, Urakaze M, Haruta T, Kishimoto T, Naka T, Kobayashi M Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression. Diabetes, 2007-03-01;56(3):795-803. 2007-03-01 [PMID: 17327450] (Mouse)
• Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis AJ, Horvath S Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet., 2006-07-05;2(8):e130. 2006-07-05 [PMID: 16934000] (Mouse)

Bioinformatics

• Gene Symbol: Adipoq