MMP-12 Antibody (82902)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IP, AP
Clone
82902
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

MMP-12 Antibody (82902) Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human MMP-12
Specificity
Detects human MMP‑12 Catalytic Domain. Does not recognize the C-terminal hemopexin-like domain of human MMP-12. Does not cross-react with recombinant human MMP-1, -2, -3, -7, -8, -9, -10, or -13.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
MMP12
Purity
Protein A or G purified from ascites
Purity Statement
Protein A or G purified from ascites
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunoaffinity Purification
  • Immunohistochemistry 8-25 ug/mL
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB919 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from ascites
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MMP-12 Antibody (82902)

  • EC 3.4.24
  • hME
  • HMEEC 3.4.24.65
  • Macrophage elastase
  • macrophage metalloelastase
  • matrix metallopeptidase 12 (macrophage elastase)
  • matrix metalloproteinase 12 (macrophage elastase)
  • Matrix metalloproteinase-12
  • ME
  • MGC138506
  • MME
  • MMP12
  • MMP-12

Background

MMP-12, also known as macrophage elastase, is a zinc and calcium dependent endopeptidase expressed constitutively in macrophages and can be induced in monocytes. MMP-12 can degrade a broad spectrum of substrates, including type IV collagen, fibronectin, laminin, vitronectin, proteoglycans, chondroitin sulfate, myelin basic protein, alpha 1-antitrypsin, and plasminogen. It can also activate MMP-2 and MMP-3. The MMP-12 precursor consists of a pro domain, a catalytic domain containing the zinc-binding site, and a C-terminal hemopexin-like domain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MMP-12 Antibody (MAB919)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: Flow Cytometry, IHC, Immunoprecipitation, Neutralization, Western Blot.


Filter By Application
Flow Cytometry
(1)
IHC
(2)
Immunoprecipitation
(1)
Neutralization
(1)
Western Blot
(3)
All Applications
Filter By Species
Human
(8)
All Species
Showing Publications 1 - 8 of 8.
Publications using MAB919 Applications Species
M Asakage, Y Usui, N Nezu, H Shimizu, K Tsubota, K Umazume, N Yamakawa, T Umezu, H Suwanai, M Kuroda, H Goto Comprehensive Gene Analysis of IgG4-Related Ophthalmic Disease Using RNA Sequencing J Clin Med, 2020;9(11):. 2020 [PMID: 33121169] (IHC, Human) IHC Human
Marina Beltrami-M, Amélie Vromman, Galina K Sukhova, Eduardo J Folco, Peter Libby Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling. PLoS ONE, 2016;0(0):1932-6203. 2016 [PMID: 27032103] (Western Blot, Human) Western Blot Human
Wang P, Chen S, Hung W, Paul C, Zhu F, Guan P, Huso D, Kontrogianni-Konstantopou A, Konstantopoulos K Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways. Oncogene, 2015;34(35):4558-69. 2015 [PMID: 25435370] (Neutralization, Human) Neutralization Human
Kong MY, Gaggar A, Li Y Matrix metalloproteinase activity in pediatric acute lung injury. Int J Med Sci, 2009;6(1):9-17. 2009 [PMID: 19159011] (Western Blot, Human) Western Blot Human
Dean RA, Cox JH, Bellac CL, Doucet A, Starr AE, Overall CM Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood, 2008;112(8):3455-64. 2008 [PMID: 18660381] (Western Blot, Human) Western Blot Human
Coury F, Annels N, Rivollier A, Olsson S, Santoro A, Speziani C, Azocar O, Flacher M, Djebali S, Tebib J, Brytting M, Egeler RM, Rabourdin-Combe C, Henter JI, Arico M, Delprat C Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. Nat. Med., 2007;14(1):81-7. 2007 [PMID: 18157139] (Flow Cytometry, Human) Flow Cytometry Human
Rust R, Kluiver J, Visser L, Harms G, Blokzijl T, Kamps W, Poppema S, Van Den Berg A Gene expression analysis of dendritic/Langerhans cells and Langerhans cell histiocytosis. J. Pathol., 2006;209(4):474-83. 2006 [PMID: 16718746] (IHC, Human) IHC Human
Lavigne MC, Thakker P, Gunn J, Miyashiro JS, Wasserman AM, Wei SQ, Pelker JW Human bronchial epithelial cells express and secrete MMP-12. Biochem. Biophys. Res. Commun., 2004;324(2):534-46. 2004 [PMID: 15474460] (Immunoprecipitation, Human) Immunoprecipitation Human

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol MMP12