MMP-12 Products

Description

Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested. It is therefore an attractive therapeutic target (1). MMP-12) expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3).

Bioinformatics

Entrez	4321 Human 17381 Mouse 117033 Rat
Uniprot	MM12_HUMAN Human NM_002426 Human P39900 Human NP_002417 Human NP_002417.2 Human
Product By Gene ID	4321
Alternate Names	MME EC 3.4.24 ME hME Matrix metalloproteinase-12 macrophage metalloelastase Macrophage elastase MGC138506 matrix metalloproteinase 12 (macrophage elastase) HMEEC 3.4.24.65 MMP-12 matrix metallopeptidase 12 (macrophage elastase)

Diseases related to MMP-12

Discover more about diseases related to MMP-12.

Inflammation
Lung Diseases
Malignant Neoplasms
Neoplasms
Pulmonary Emphysema
Chronic Obstructive Airway Disease
Lung Diseases, Obstructive
Carcinoma
Cell Invasion
Neoplasm Metastasis
Fibrosis
Tumor Angiogenesis
Atherosclerosis
Neoplasm Invasiveness
Inflammatory Response
Malignant Squamous Cell Neoplasm
Pathologic Neovascularization
Aneurysm
Asthma
Lung Neoplasms

Pathways for MMP-12

View related products by pathway and learn more about each of the pathways below.

Pathogenesis
Angiogenesis
Inflammatory Response
Tissue Remodeling
Proteolysis
Localization
Secretion
Cell Migration
Cell Proliferation
Macrophage Activation
Immune Response
Wound Healing
Cell Adhesion
Cell Differentiation
Cell Cycle
Cell Growth
Dna Replication
Dedifferentiation
Aging
Tube Formation

PTMs for MMP-12

Learn more about PTMs related to MMP-12.

Cleavage
Phosphorylation
Oxidation
Acetylation
Dephosphorylation

Bioinformatics Tool for MMP-12

Discover related pathways, diseases and genes to MMP-12. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related MMP-12 Blog Posts

Check out the latest blog posts on MMP-12.

MCP-1 - chemoattractant protein involed in monocyte migration and infiltration Monocyte chemotractant protein-1 (MCP-1), also known as CCL2, is a key chemokine involved in the migration of monocytes and macrophages to sites of active inflammation. It is a member of the C-C/beta family of cytokines, characterized by the Cys-C...    Read more.

Read more MMP-12 related blogs.