MMP-12 Products

Description

Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested. It is therefore an attractive therapeutic target (1). MMP-12) expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3).

Bioinformatics

Product By Gene ID	4321
Alternate Names	EC 3.4.24 hME HMEEC 3.4.24.65 Macrophage elastase macrophage metalloelastase matrix metallopeptidase 12 (macrophage elastase) matrix metalloproteinase 12 (macrophage elastase) Matrix metalloproteinase-12 ME MGC138506 MME MMP12 MMP-12

Related MMP-12 Blog Posts

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MCP-1 - chemoattractant protein involed in monocyte migration and infiltration Monocyte chemotractant protein-1 (MCP-1), also known as CCL2, is a key chemokine involved in the migration of monocytes and macrophages to sites of active inflammation. It is a member of the C-C/beta family of cytokines, characterized by the Cys-C...    Read more.

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