MMP-12 Products

Antibodies
MMP-12 Antibody
MMP-12 Antibody
NBP1-31225
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MMP-12 Antibody (82902)
MMP-12 Antibody (82902)
MAB919
Species: Hu
Applications: WB, IHC, IP, AP
Host: Mouse Monoclonal
MMP-12 Antibody [Unconjugated ...
MMP-12 Antibody [Unconjugated]
AF917
Species: Hu
Applications: WB, IHC, IP
Host: Goat Polyclonal
Antibody Pairs
MMP-12 Antibody Pair
MMP-12 Antibody Pair
H00004321-PW2
Species: Hu
Applications: WB, IP
ELISA Kits
MMP-12 ELISA Kit
MMP-12 ELISA Kit
DDXK-E-MMP12-1
Species: Hu
Applications: ELISA
Lysates
MMP-12 Overexpression Lysate ...
MMP-12 Overexpression Lysate (Native)
NBL1-13151
Applications: WB
MMP-12 Overexpression Lysate ...
MMP-12 Overexpression Lysate (Dena...
H00004321-T01
Applications: WB
Proteins
MMP-12 Recombinant Protein
MMP-12 Recombinant Protein
H00004321-P01
Species: Hu
Applications: WB, ELISA, PA
MMP-12 Partial Recombinant Pr ...
MMP-12 Partial Recombinant Protein
H00004321-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
MMP-12 RNAi
MMP-12 RNAi
H00004321-R01
Species: Hu

Description

Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested. It is therefore an attractive therapeutic target (1). MMP-12) expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 4321
Alternate Names
  • MME
  • EC 3.4.24
  • ME
  • hME
  • Matrix metalloproteinase-12
  • macrophage metalloelastase
  • Macrophage elastase
  • MGC138506
  • matrix metalloproteinase 12 (macrophage elastase)
  • HMEEC 3.4.24.65
  • MMP-12
  • matrix metallopeptidase 12 (macrophage elastase)

PTMs for MMP-12

Learn more about PTMs related to MMP-12.

Cleavage
Phosphorylation
Oxidation
Acetylation
Dephosphorylation

Bioinformatics Tool for MMP-12

Discover related pathways, diseases and genes to MMP-12. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related MMP-12 Blog Posts

Check out the latest blog posts on MMP-12.
MCP-1 - chemoattractant protein involed in monocyte migration and infiltration
Monocyte chemotractant protein-1 (MCP-1), also known as CCL2, is a key chemokine involved in the migration of monocytes and macrophages to sites of active inflammation. It is a member of the C-C/beta family of cytokines, characterized by the Cys-C...    Read more.
Read more MMP-12 related blogs.