Mer Antibody (S07-6H2)

Western Blot: Mer Antibody (S07-6H2) [NBP3-14954] - Western blot detection of Mer in MCF-7, 293T cell lysates using Mer Rabbit mAb (1:1000 diluted). Predicted band size: 110kDa. Observed band size: 210kDa.

Immunohistochemistry-Paraffin: Mer Antibody (S07-6H2) [NBP3-14954] - Immunohistochemistry of Mer in paraffin-embedded Human tonsil using Mer Rabbit mAb at dilution 1/50

• Reactivity: Hu
• Applications: WB, IHC
• Clone: S07-6H2
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

Mer Antibody (S07-6H2) Summary

• Description: Novus Biologicals Rabbit Mer Antibody (S07-6H2) (NBP3-14954) is a recombinant monoclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthetic peptide of human Mer (Uniprot#: Q12866)
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: MERTK
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1/50-1/500
  • Immunohistochemistry-Paraffin
  • Western Blot 1/1000
• Theoretical MW: 210 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA
• Preservative: 0.01% Sodium Azide
• Purity: Affinity purified

Alternate Names for Mer Antibody (S07-6H2)

• c-Eyk
• c-mer proto-oncogene tyrosine kinase
• C-mer
• EC 2.7.10
• EC 2.7.10.1
• MER receptor tyrosine kinase
• Mer
• MerTK
• MGC133349
• Receptor tyrosine kinase MerTK
• RP38Proto-oncogene c-Mer
• STK kinase
• tyrosine-protein kinase Mer

Background

MerTK (c-mer, Nyk, Eyk) is a tyrosine kinase that belongs to a family of transmembrane receptors (1). MerTk has been implicated in reversible cell growth arrest, survival, proliferation and cell adhesion. Growth arrest specific protein 6 (Gas6) is an activating ligand for MerTK (2-3). MerTK is required for clearance of apoptotic cells by mononuclear phagocytes in mice; with its absence resulting in progressive lupus like autoimmunity (4). Defects in MERTK are a cause of retinitis pigmentosa (RP) (5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MERTK