MAVS Antibody - BSA Free

Western Blot: MAVS Antibody [NBP1-76768] - Rat brain tissue lysate with MAVS antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

Immunohistochemistry: MAVS Antibody - BSA Free [NBP1-76768] - Immunohistochemistry of MAVS in mouse brain tissue with MAVS antibody at 2.5 u/mL.

Immunocytochemistry/ Immunofluorescence: MAVS Antibody - BSA Free [NBP1-76768] - Immunofluorescence of MAVS in Mouse Brain cells with MAVS antibody at 20 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

MAVS Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit MAVS Antibody - BSA Free (NBP1-76768) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 17 amino acid synthetic peptide from near the center of human VISA. The immunogen is located within amino acids 130 - 180 of VISA. Amino Acid Squence: MPVQETQAPESPGENSE
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MAVS
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
  • Western Blot 0.5-2 ug/ml
• Control Peptide:

  MAVS Peptide (NBP1-76768PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for MAVS Antibody - BSA Free

• CARD adapter inducing interferon beta
• CARD adapter inducing interferon-beta
• CARD adaptor inducing IFN-beta
• Cardif
• DKFZp547C224
• DKFZp666M015
• FLJ27482
• IFN-B promoter stimulator 1
• Interferon beta promoter stimulator protein 1
• interferon-beta promoter stimulator protein 1
• IPS-1
• IPS-1FLJ41962
• IPS1MGC3260
• KIAA1271FLJ35386
• MAVS
• mitochondrial antiviral signaling protein
• mitochondrial antiviral-signaling protein
• mitochondrial viral signaling protein
• Putative NF-kappa-B-activating protein 031N
• virus-induced signaling adapter variant 1b
• virus-induced signaling adaptor variant 1a
• Virus-induced-signaling adapter
• VISA
• VISAFLJ38051

Background

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for MAVS Antibody (NBP1-76768). (Showing 1 - 1 of 1 FAQ).

1. Molecular weight of MAVS?
   • MAVS is a 540 aa protein with a predicted size of 56 kDa.

Bioinformatics

• Gene Symbol: MAVS
• Entrez:
  • 57506(Human)
  • 228607(Mouse)
  • 311430(Rat)
• Uniprot:
  • Q7Z434()