MAGP-2/MFAP5 Antibody [Biotin]

• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Biotin
• Concentration: LYOPH

MAGP-2/MFAP5 Antibody [Biotin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human MAGP-2/MFAP5
• Specificity: Detects human MAGP-2/MFAP5 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human MAGP-1 is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: MFAP5
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

MAGP-2 (Microfibril-associated glycoprotein 2; also MFAP-5) is a 25 kDa member of the MFAP family of proteins. It is secreted by smooth muscle cells and has multiple functions. Through its binding to EGF repeats, MAGP-2 mediates the release of Jagged1 and Notch extracellular domains, and also binds to matrix microfibrillar proteins, inducing elastin fiber formation. Mature human MAGP-2 is 152 amino acids (aa) in length. It contains an RDG motif (aa 30‑32) and a central Cys-rich domain (aa 84‑140) that participates in covalent binding to fibrillin microfibrils. One potential splice variant exists that shows a 10 aa deletion between aa 73‑82. Mature human MAGP-2 is 86% and 87% aa identical to mouse and canine MAGP-2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MFAP5