LYVE-1 Antibody [Biotin] Summary
A synthetic peptide made to a C-terminal portion of the mouse LYVE1 protein sequence (between residues 250-318). [UniProt# Q8BHC0]
Lymphatic Vessel Marker
Immunogen affinity purified
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Packaging, Storage & Formulations
Store at 4C in the dark.
Biotin (A=N/A, E=N/A)
0.05% Sodium Azide
Immunogen affinity purified
- Western Blot 1:500-1:2000
- Flow Cytometry 1:25
- Immunocytochemistry/Immunofluorescence 1:100
- Immunohistochemistry 1:100-1:200
- Immunohistochemistry-Paraffin 1:100-1:200
This LYVE1 antibody is useful for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin and Western Blot where a band at ~45 kDa is seen. For Immunohistochemistry citrate buffer antigen retrieval is recommended.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Alternate Names for LYVE-1 Antibody [Biotin]
- cell surface retention sequence binding protein-1
- Cell surface retention sequence-binding protein 1
- extracellular link domain containing 1
- extracellular link domain-containing 1
- Extracellular link domain-containing protein 1
- Hyaluronic acid receptor
- lymphatic vessel endothelial hyaluronan receptor 1
- lymphatic vessel endothelial hyaluronic acid receptor 1
The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, and podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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