LYVE-1 Products

Description

LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.

Bioinformatics

Entrez	10894 Human 114332 Mouse
Uniprot	Q9Y5Y7 Human NP_006682 Human NM_006691 Human AAH26231 Human AAH26231.1 Human Q8BHC0 Mouse
Product By Gene ID	10894
Alternate Names	CRSBP-1 CRSBP1 Hyaluronic acid receptor lymphatic vessel endothelial hyaluronic acid receptor 1 Extracellular link domain-containing protein 1 extracellular link domain-containing 1 Cell surface retention sequence-binding protein 1 cell surface retention sequence binding protein-1 extracellular link domain containing 1 LYVE-1XLKD1 HAR lymphatic vessel endothelial hyaluronan receptor 1

Diseases related to LYVE-1

Discover more about diseases related to LYVE-1.

Neoplasms
Neoplasm Metastasis
Malignant Neoplasms
Lymphatic Metastasis
Metastatic Malignant Neoplasm To The Lymph Node
Carcinoma
Cell Invasion
Pathologic Neovascularization
Tumor Angiogenesis
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Breast
Mammary Neoplasms
Inflammation
Von Willebrand Disease
Neoplasm Invasiveness
Melanoma
Malignant Squamous Cell Neoplasm
Headache
Tissue Adhesions
Stomach Neoplasms

Pathways for LYVE-1

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Lymphangiogenesis
Angiogenesis
Secretion
Pathogenesis
Transport
Cell Adhesion
Cell Migration
Localization
Cell Proliferation
Wound Healing
Cell Growth
Regulation Of Lymphangiogenesis
Tube Formation
Immune Response
Tissue Remodeling
Cell Activation
Vasculogenesis
Cell Maturation
Tissue Development
Cell Motility

Research Areas for LYVE-1

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Endosome Markers
Endothelial Cell Markers
Immunology

PTMs for LYVE-1

Learn more about PTMs related to LYVE-1.

Sulphation
Glycosylation
Acetylation

Bioinformatics Tool for LYVE-1

Discover related pathways, diseases and genes to LYVE-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related LYVE-1 Blog Posts

Check out the latest blog posts on LYVE-1.

Meningeal lymphatics: recent discovery defying the concept of central nervous system 'immune privilege' By Jennifer Sokolowski, MD, PhD. Identification and characterization of meningeal lymphaticsThe recent discovery of a lymphatic system in the meninges surrounding the brain and spinal cord has spurred a surge of int...    Read more.

Read more LYVE-1 related blogs.