Lymphotoxin beta R/TNFRSF3 Antibody [Biotin]

• Applications: WB, Flow, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Biotin
• Concentration: LYOPH

Lymphotoxin beta R/TNFRSF3 Antibody [Biotin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Lymphotoxin beta R/TNFRSF3
  Ser28-Pro218
  Accession # P50284
• Specificity: Detects Lymphotoxin beta R/TNFRSF3 in Western blots. In Western blots, approximately 10% cross-reactivity with recombinant human (rh) LT beta R is observed and less than 1% cross-reactivity with recombinant mouse (rm) 4-1BB, rmCD27, rmCD30, rmCD40, rmEDAR, rmFas, rmGITR, rmOPG, rmRANK, rmTNF RI, and rmTNF RII is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: LTBR
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Lymphotoxin beta receptor (LTbR), also known as TNFRSF3, TNF RIII, and TNF Rrp, is a transmembrane receptor for the homotrimeric LIGHT/TNFSF14 and the heterotrimeric LTalpha1/beta2. LTbR engagement induces production of IL-7, RANK, TRANCE/RANK L, VEGF-C, the adhesion molecules VCAM-1, ICAM-1, and MAdCAM, and the chemokines CXCL13, CCL19 and CCL21. LTbR is expressed on mesenchymal stromal organizing cells that give rise to stroma of primary (thymus), secondary (tonsils, lymph nodes, and Peyers patches) and tertiary (ectopic inflammatory) lymphoid structures. It is expressed by hepatocytes and is upregulated in regeneration, hepatitis, and hepatocellular carcinoma where it regulates lipid metabolismd. A soluble form of LTbR can be released and functions an inhibitor of transmembrane LTbR.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LTBR