Lymphotoxin beta R/TNFRSF3 Products

Description

LT-beta-R, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LT-beta-R is a receptor for the heterotrimeric lymphotoxin complex (composed of LT alpha and LT beta as well as LIGHT. LT-beta-R is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LT-beta-R is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LT-beta-R interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LT-beta-R has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs.

Bioinformatics

Entrez	17000 Mouse 4055 Human
Uniprot	AAH26262 Human NM_002342 Human NP_002333.1 Human P36941 Human P50284 Mouse
Product By Gene ID	4055
Alternate Names	CD18 D12S370 ltbetar LT-beta-R LT-BETA-R lymphotoxin B receptor lymphotoxin beta receptor (TNFR superfamily, member 3) Lymphotoxin-beta receptor TNFCRTNF-RIII TNFR superfamily, member 3 TNFR2-RP TNFR3 TNF-R-III TNFR-RP TNFRSF3TNFR-III Tumor necrosis factor C receptor Tumor necrosis factor receptor 2-related protein tumor necrosis factor receptor superfamily member 3 tumor necrosis factor receptor superfamily, member 3 Tumor necrosis factor receptor type III

Research Areas for Lymphotoxin beta R/TNFRSF3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cytokine Research