Lgr5/GPR49 Antibody

Images

 
Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody [NLS1236] - Analysis of anti-GPR49 antibody with human colon.
Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody [NLS1236] - Analysis of anti-GPR49 antibody with human, small intestine.

Product Details

Summary
Reactivity Hu, Bt, Bv, Ha, Mk, Pm, RbSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Lgr5/GPR49 Antibody Summary

Immunogen
Synthetic 20 amino acid peptide from 1st cytoplasmic domain of human GPR49 / LGR5.
Specificity
Human GPR49 / LGR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Monkey (100%), Bat (95%), Primate (95%), Rabbit (90%), Bovine (95%), Hamster (90%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LGR5
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1.8 ug/ml
Positive Control
Lgr5/GPR49 Lysate (NBL1-12509)
Publications
Read Publication using NLS1236.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (100%), Marmoset (95%), Elephant (90%), Panda (90%), Mouse (85%), Rat (85%), Opossum (85%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS and 10% Glycerol
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Lgr5/GPR49 Antibody

  • FEX
  • G protein-coupled receptor 49
  • GPR49
  • GPR49G-protein coupled receptor HG38
  • GPR67
  • G-protein coupled receptor 49
  • G-protein coupled receptor 67
  • GRP49
  • HG38
  • leucine-rich repeat containing G protein-coupled receptor 5
  • leucine-rich repeat-containing G protein-coupled receptor 5
  • leucine-rich repeat-containing G-protein coupled receptor 5
  • Lgr5
  • MGC117008
  • orphan G protein-coupled receptor HG38

Background

GPR49 is an Orphan-A GPCR with an unknown ligand. G protein-coupled receptor GPR49 has been reported to be expressed in brain, skeletal muscle, placenta, and spinal cord. Recent evidence suggests that GPR49 may be involved in the proliferation of cancer cells. GPR49 is over-expressed in both ovarian and colon primary tumors as well as in basal cell carcinomas. Over-expression of GPR49 increases cell proliferation in a human keratinocyte cell line and conveys the ability to form tumors when transplanted into immunodeficient mice. GPR49 appears to act downstream of HedgeHog (Hh) signaling and may be responsible for increased cell proliferation and tumor formation in several types of cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Lgr5/GPR49 Antibody (NLS1236)(1)

We have publications tested in 1 confirmed species: Rat.


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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol LGR5
Entrez