Kremen-2 Antibody [Janelia Fluor® 646]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Janelia Fluor 646

Kremen-2 Antibody [Janelia Fluor® 646] Summary

• Immunogen: Antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human Kremen-2. The immunogen is located within amino acids 390-440 of Kremen-2. Amino Acid Sequence: ALGASRGGPRRSWAV
• Specificity: Multiple isoforms of Kremen-2 are known to exist. Kremen-2 antibody is predicted to not cross-react with other Kremen protein family members. Human Kremen-2 has 6 isoforms, including isoform 1 (462aa, 49kD), isoform 2 (424aa, 45kD), isoform 3 (420aa, 44kD), isoform 4 (399aa, 42kD), isoform 5 (423aa, 45kD), and isoform 6 (381aa, 40kD). Mouse Kremen-2 has one isoform (461aa, 49kD) and rat Kremen-2 also has one isoform (468aa, 50kD). NBP2-22339 can detect human, mouse and rat.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KREMEN2
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Peptide affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Kremen-2 Antibody [Janelia Fluor® 646]

• Dickkopf receptor 2
• kremen protein 2
• Kremen2
• Kremen-2
• kringle containing transmembrane protein 2
• Kringle domain-containing transmembrane protein 2
• KRM2Kringle-containing protein marking the eye and the nose
• MGC10791
• MGC16709

Background

KREMEN2 encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KREMEN2