Kremen-2 Products

Description

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. Transcript Variant: This variant (2), also called kremen2b, lacks an exon in the 3' coding region compared to variant 4, resulting in a frameshift and an isoform (b) with a shorter and different C-terminus compared to isoform d.

Bioinformatics

Product By Gene ID	79412
Alternate Names	Dickkopf receptor 2 kremen protein 2 Kremen2 Kremen-2 kringle containing transmembrane protein 2 Kringle domain-containing transmembrane protein 2 KRM2Kringle-containing protein marking the eye and the nose MGC10791 MGC16709

Research Areas for Kremen-2

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Signal Transduction