Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, Flow, CyTOF-ready
Host: Goat Polyclonal
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Binding Activity
Species: Rt
Applications: Binding Activity
Species: Hu
Applications: Binding Activity
Description
KREMEN2 encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
79412 |
| Alternate Names |
- Dickkopf receptor 2
- kremen protein 2
- kringle containing transmembrane protein 2
- Kringle domain-containing transmembrane protein 2
- KRM2Kringle-containing protein marking the eye and the nose
- MGC10791
- MGC16709
|
Research Areas for Kremen-2
Find related products by research area and learn more about each of the different research areas below.
Signal Transduction
