Kininogen/Kininostatin/Bradykinin Antibody [HRP]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: HRP

Kininogen/Kininostatin/Bradykinin Antibody [HRP] Summary

• Immunogen: E. coli-derived recombinant human Kininostatin
  Lys438-Ser531
  Accession # P01042
• Specificity: Detects human Kininogen/Kininostatin in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: KNG1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Antigen Affinity-purified

Alternate Names for Kininogen/Kininostatin/Bradykinin Antibody [HRP]

• Alpha-2-thiol proteinase inhibitor
• BDK
• bradykinin
• Fitzgerald factor
• High molecular weight kininogen
• kininogen 1
• kininogen
• Kininogen/Kininostatin
• kininogen-1
• KNGHMWK
• Williams-Fitzgerald-Flaujeac factor

Background

Bradykinin is a nine amino acid vasoactive peptide which elicits numerous physiologic responses such as vasodilation, smooth muscle spasm and pain. Bradykinin is one of a family of such peptides called the kinins. These kinins are generated by proteolysis of high molecular weight precursors called kininogens upon activation by pathophysiologic conditions such as inflammation or allergy. The physiological actions of these kinins are brought about through their interaction with transmembrane receptors. There are two distinct bradykinin receptor subtypes; B1 and B2, both of which appear to be coupled to G-proteins. The B2 receptor subtype is found in healthy smooth muscle cells and neurons, whereas the B1 receptors are only detected following tissue injury. The B2 receptor is similar in structure to other seven helix G protein coupled receptors. Bradykinin has relatively low affinity for B1 receptors, interacting primarily with the B2 receptor through which several second messenger systems are stimulated, including inositol phospholipid hydrolysis, arachidonic acid metabolism, tyrosine phosphorylation, and membrane depolarization and hyperpolarization.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KNG1