KA2/GRIK5/Glutamate Receptor KA2 Antibody (2916E) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: IHC
• Clone: 2916E
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 488

KA2/GRIK5/Glutamate Receptor KA2 Antibody (2916E) [Alexa Fluor® 488] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Synthetic peptide sequence
  Accession # Q16478
• Specificity: Detects human KA2/GRIK5 in direct ELISA.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for KA2/GRIK5/Glutamate Receptor KA2 Antibody (2916E) [Alexa Fluor® 488]

• EAA2
• Excitatory amino acid receptor 2
• GluK5
• glutamate receptor KA2
• Glutamate receptor KA-2
• glutamate receptor, ionotropic kainate 5
• glutamate receptor, ionotropic, kainate 5
• GRIK2
• GRIK5
• KA2/GRIK5
• KA2GRIK2

Background

GRIK5 (Glutamate receptor, ionotropic kainate 5) is a receptor for glutamate and is one of the 5 types of kainate receptor subunits.  L-Glutamate acts as an excitatory neurotransmitter at many synapses in the CNS. The GRIK5 protein forms functional heteromic kainate-preferring ionic channels with the subunits encoded by related gene family members.  Kainate receptors have both presynaptic and postsynaptic actions and a limited distribution in the brain. Kainate receptors have been shown to have connections with several neurological diseases and conditions.  There is linkage to schizophrenia, depression, autism, Huntington's, bipolar disorder, and epilepsy among others.  KA2 is relatively abundant in all areas of the brain, most notably in dentate gyrus, pyramidal neurons of CA3, cerebellar granule cells, as well as being present in superficial and deep laminae of the neocortex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.