Isocitrate Dehydrogenase 1/IDH1 Antibody (IDH1/1152) [Alexa Fluor® 594]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, IHC-P, ICC/IF
Clone
IDH1/1152
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 594

Order Details

Isocitrate Dehydrogenase 1/IDH1 Antibody (IDH1/1152) [Alexa Fluor® 594] Summary

Immunogen
Recombinant fragment (119 Amino acid residues around aa 280-420) of human IDH1 protein
Localization
Cytoplasmic & Nuclear
Specificity
It recognizes a 45kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
IDH1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Isocitrate Dehydrogenase 1/IDH1 Antibody (IDH1/1152) [Alexa Fluor® 594]

  • Cytosolic NADP-isocitrate dehydrogenase
  • EC 1.1.1.42
  • IDCD
  • IDH
  • IDH1
  • IDP
  • IDPC
  • isocitrate dehydrogenase [NADP] cytoplasmic
  • isocitrate dehydrogenase 1 (NADP+), soluble
  • Isocitrate Dehydrogenase 1
  • NADP(+)-specific ICDH
  • NADP-dependent isocitrate dehydrogenase, cytosolic
  • NADP-dependent isocitrate dehydrogenase, peroxisomal
  • Oxalosuccinate decarboxylase
  • PICD

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NBP2-47744AF594
Species: Hu
Applications: WB, Flow, IHC, IHC-P, ICC/IF

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47744AF350
Alexa Fluor 405 NBP2-47744AF405
Alexa Fluor 488 NBP2-47744AF488
Alexa Fluor 532 NBP2-47744AF532
Alexa Fluor 594 NBP2-47744AF594
Alexa Fluor 647 NBP2-47744AF647
Alexa Fluor 700 NBP2-47744AF700
Alexa Fluor 750 NBP2-47744AF750
Allophycocyanin NBP2-47744APC
Biotin NBP2-47744B
DyLight 350 NBP2-47744UV
DyLight 405 NBP2-47744V
DyLight 488 NBP2-47744G
DyLight 550 NBP2-47744R
DyLight 594 NBP2-47744DL594
DyLight 650 NBP2-47744C
DyLight 680 NBP2-47744FR
DyLight 755 NBP2-47744IR
FITC NBP2-47744F
HRP NBP2-47744H
Janelia Fluor 549 NBP2-47744JF549
Janelia Fluor 646 NBP2-47744JF646
PE NBP2-47744PE
PerCP NBP2-47744PCP

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Bioinformatics

Gene Symbol IDH1