Isocitrate Dehydrogenase 1/IDH1 Products

Antibodies
Isocitrate Dehydrogenase 1/ID ...
Isocitrate Dehydrogenase 1/IDH1 An...
NBP1-47804
Species: Hu, Mk
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Isocitrate Dehydrogenase 1/ID ...
Isocitrate Dehydrogenase 1/IDH1 An...
NBP2-46018
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
Isocitrate Dehydrogenase 1/ID ...
Isocitrate Dehydrogenase 1/IDH1 An...
MAB7049
Species: Hu
Applications: WB, IHC, ICC
Host: Mouse Monoclonal
Proteins
Isocitrate Dehydrogenase 1/ID ...
Isocitrate Dehydrogenase 1/IDH1 Re...
NBP2-34091PEP
Species: Hu
Applications: AC
Isocitrate Dehydrogenase 1/ID ...
Isocitrate Dehydrogenase 1/IDH1 Re...
NBP1-87428PEP
Species: Hu
Applications: AC
Isocitrate Dehydrogenase 1/ID ...
Isocitrate Dehydrogenase 1/IDH1 Re...
NBP2-52882PEP
Species: Hu
Applications: AC

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq]

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 3417
Alternate Names
  • EC 1.1.1.42
  • Cytosolic NADP-isocitrate dehydrogenase
  • NADP(+)-specific ICDH
  • NADP-dependent isocitrate dehydrogenase, peroxisomal
  • PICD
  • NADP-dependent isocitrate dehydrogenase, cytosolic
  • IDP
  • isocitrate dehydrogenase [NADP] cytoplasmic
  • IDH
  • IDPC
  • Oxalosuccinate decarboxylase
  • IDCD
  • isocitrate dehydrogenase 1 (NADP+), soluble

Research Areas for Isocitrate Dehydrogenase 1/IDH1

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Stem Cell Markers

PTMs for Isocitrate Dehydrogenase 1/IDH1

Learn more about PTMs related to Isocitrate Dehydrogenase 1/IDH1.

Methylation
Demethylation
Decarboxylation
Phosphorylation
Carboxylation
Reduction
Hydroxylation
Cleavage
Nitration
Deacetylation

Bioinformatics Tool for Isocitrate Dehydrogenase 1/IDH1

Discover related pathways, diseases and genes to Isocitrate Dehydrogenase 1/IDH1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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