Integrin alpha L/CD11a Antibody (MEM-25) [Biotin] Summary
Leucocytes from a patient suffering from a LGL-type leukemia (NM_001114380.1).
The antibody MEM-25 reacts with CD11a (alpha subunit of human LFA-1), a 170-180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils. HLDA IV; WS Code NL 209
Protein A purified
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Biotin (A=N/A, E=N/A)
PBS (pH 7.4)
15mM Sodium Azide
Protein A purified
Flow Cytometry: use at an assay-dependent dilution Immunoprecipitation: use at an assay-dependent dilutions (suitable for immunoaffinity purification of LFA-1 complex). Functional Applications: use at an assay-dependent dilution (blocks binding of LFA-1 complex to ICAM-1) Other applications have not been tested. Optimal dilutions should be determined by end-user. Purity is > 95% (by SDS-PAGE).
Alternate Names for Integrin alpha L/CD11a Antibody (MEM-25) [Biotin]
- CD11 antigen-like family member A
- CD11a antigen
- CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide
- integrin alpha-L
- integrin gene promoter
- integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide)
- Leukocyte adhesion glycoprotein LFA-1 alpha chain
- Leukocyte function-associated molecule 1 alpha chain
- LFA-1 alpha
- lymphocyte function-associated antigen 1
CD11a (LFA-1a) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the aLb2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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