Integrin alpha 4/CD49d Antibody (2B4)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications B/N
Clone
2B4
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

Integrin alpha 4/CD49d Antibody (2B4) Summary

Immunogen
U937 human histiocytic lymphoma cell line
Specificity
Detects human Integrin alpha 4 subunit (Needham, L.A. et al. (1994) Cell Adhesion and Communication 2:87).
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGA4
Purity
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Adhesion Blockade
Publications
Read Publications using
BBA37 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Sterile PBS to a final concentration of 0.2 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin alpha 4/CD49d Antibody (2B4)

  • 269C wild type
  • CD49 antigen-like family member D
  • CD49d antigen
  • CD49d
  • CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor
  • IA4
  • Integrin alpha 4
  • integrin alpha-4 subunit
  • integrin alpha-4
  • Integrin alpha-IV
  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
  • ITGA4
  • MGC90518
  • very late activation protein 4 receptor, alpha 4 subunit
  • VLA-4 subunit alpha
  • VLA-4

Background

Integrin alpha 4, also known as CD49d, is a transmembrane protein that forms heterodimers with beta 1 or beta 7 integrins. These complexes contribute to the trafficking of many hematopoietic cell types. Integrins alpha 4 beta 1 (also known as VLA-4) and alpha 4 beta 7 (LPAM-1) are receptors for fibronectin, VCAM and MAdCAM-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Integrin alpha 4/CD49d Antibody (BBA37)(9)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Blocking, Flow, ICC, Neut.


Filter By Application
Blocking
(1)
Flow
(1)
ICC
(1)
Neut
(6)
All Applications
Filter By Species
Human
(7)
Mouse
(2)
All Species
Showing Publications 1 - 9 of 9.
Publications using BBA37 Applications Species
H Kebir, L Carmant, F Fontaine, K Béland, CM Bosoi, NT Sanon, JI Alvarez, S Desgent, CL Pittet, D Hébert, MJ Langlois, RM Rébillard, DK Nguyen, C Cieuta-Wal, GL Holmes, HP Goodkin, JR Mytinger, MB Connolly, A Prat, E Haddad Humanized mouse model of Rasmussen&#039;s encephalitis supports the immune-mediated hypothesis J. Clin. Invest., 2018;0(0):. 2018 [PMID: 29629902] (Neut,, Mouse) Neut Mouse
ME Vogel, G Idelman, ES Konaniah, SD Zucker Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling J Am Heart Assoc, 2017;6(4):. 2017 [PMID: 28365565] (Neut,, Human) Neut Human
Yoon S, Lee I, Zhang X, Zapata M, Choi Y CD9 may contribute to the survival of human germinal center B cells by facilitating the interaction with follicular dendritic cells. FEBS Open Bio, 2014;4(0):370-6. 2014 [PMID: 24918051] (Flow,, Human) Flow Human
Kang I, Yoon D, Braun K, Wight T Expression of versican V3 by arterial smooth muscle cells alters tumor growth factor beta (TGFbeta)-, epidermal growth factor (EGF)-, and nuclear factor kappaB (NFkappaB)-dependent signaling pathways, creating a microenvironment that resists monocyte adhesion. J Biol Chem, 2014;289(22):15393-404. 2014 [PMID: 24719328] (Neut,, Human) Neut Human
Jelicic K, Cimbro R, Nawaz F, Huang D, Zheng X, Yang J, Lempicki R, Pascuccio M, Van Ryk D, Schwing C, Hiatt J, Okwara N, Wei D, Roby G, David A, Hwang I, Kehrl J, Arthos J, Cicala C, Fauci A The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-beta1 production and FcRL4 expression. Nat Immunol, 2013;14(12):1256-65. 2013 [PMID: 24162774] (Blocking,, Human) Blocking Human
Ludwig RJ, Hardt K, Hatting M, Bistrian R, Diehl S, Radeke HH, Podda M, Schon MP, Kaufmann R, Henschler R, Pfeilschifter JM, Santoso S, Boehncke WH Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Immunology, 2009;128(2):196-205. 2009 [PMID: 19740376] (Neut,, Mouse) Neut Mouse
Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S High pressure promotes monocyte adhesion to the vascular wall. Circ. Res., 2007;100(8):1226-33. 2007 [PMID: 17395876] (Neut,, Human) Neut Human
Abe Y, Fornage M, Yang CY, Bui-Thanh NA, Wise V, Chen HH, Rangaraj G, Ballantyne CM L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis, 2007;192(1):56-66. 2007 [PMID: 17022986] (Neut,, Human) Neut Human
Bug G, Rossmanith T, Henschler R, Kunz-Schughart LA, Schroder B, Kampfmann M, Kreutz M, Hoelzer D, Ottmann OG Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells. J. Leukoc. Biol., 2002;72(4):837-45. 2002 [PMID: 12377954] (ICC,, Human) ICC Human

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Bioinformatics

Gene Symbol ITGA4
Entrez