Integrin alpha 4/CD49d Products

Antibodies
Integrin alpha 4/CD49d Antibo ...
Integrin alpha 4/CD49d Antibody (2B4)
BBA37
Species: Hu
Applications: AdBlk
Host: Mouse Monoclonal
Integrin alpha 4/CD49d Antibo ...
Integrin alpha 4/CD49d Antibody (5C4)
NBP2-37503
Species: Hu
Applications: WB, ELISA, Flow
Host: Mouse Monoclonal
Lysates
Integrin alpha 4/CD49d Overex ...
Integrin alpha 4/CD49d Overexpress...
NBL1-12064
Applications: WB
Proteins
Integrin alpha 4/CD49d Partia ...
Integrin alpha 4/CD49d Partial Rec...
H00003676-Q01
Species: Hu
Applications: WB, ELISA, PA
Integrin alpha 4/CD49d Peptid ...
Integrin alpha 4/CD49d Peptide
NBP1-76355PEP
Species: Hu
Applications: AC
Integrin alpha 4/CD49d Peptid ...
Integrin alpha 4/CD49d Peptide
NBP1-77333PEP
Species: Hu
Applications: AC
RNAi
Integrin alpha 4/CD49d RNAi
Integrin alpha 4/CD49d RNAi
H00003676-R01
Species: Hu

Description

VLA-4 is a cell surface heterodimer in the integrin superfamily of adhesion receptors. Anti-VLA-4 antibodies inhibited cytolytic T cell activity, with inhibitory activity directed against the effector T cells rather than their targets. Thus, whereas other VLA receptors appear to mediate cell--matrix interactions, VLA-4 may have a cell--cell adhesion function. Alpha 4 stands apart from all other known integrin alpha subunit sequences because (i) alpha 4 has neither an inserted I-domain, nor a disulfide-linked C-terminal fragment, (ii) its sequence is the most unique and (iii) only alpha 4 has a potential protease cleavage site, near the middle of the coding region, which appears responsible for the characteristic 80,000 and 70,000 Mr fragments of alpha 4 (1). Unlike any other integrin alpha subunit, the intact (150 kDa) alpha 4 subunit of VLA-4 can sometimes be cleaved into two noncovalently associated fragments (80 and 70 kDa) (2). The VLA-4 integrins are indispensable for embryogenesis, haematopoiesis and immune responses, possibly because alpha4 regulates cellular functions differently from other integrins through its cytoplasmic tail (3).

Bioinformatics

Entrez Human
Mouse
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 3676
Alternate Names
  • IA4
  • CD49d antigen
  • 269C wild type
  • very late activation protein 4 receptor, alpha 4 subunit
  • CD49d
  • integrin alpha-4 subunit
  • VLA-4 subunit alpha
  • integrin alpha-4
  • CD49 antigen-like family member D
  • integrin alpha 4
  • Integrin alpha-IV
  • CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor
  • MGC90518
  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Research Areas for Integrin alpha 4/CD49d

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Cytoskeleton Markers
Phospho-Specific

PTMs for Integrin alpha 4/CD49d

Learn more about PTMs related to Integrin alpha 4/CD49d.

Methylation
Acetylation

Bioinformatics Tool for Integrin alpha 4/CD49d

Discover related pathways, diseases and genes to Integrin alpha 4/CD49d. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.