IMP Dehydrogenase 2/IMPDH2 Antibody

Images

 
Western Blot: IMP Dehydrogenase 2/IMPDH2 Antibody [NBP2-27195] - Analysis of IMPDH using IMPDH antibody. Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide probed with 2 ug/ml of IMPDH antibody. ...read more
Immunohistochemistry-Paraffin: IMP Dehydrogenase 2/IMPDH2 Antibody [NBP2-27195] - Analysis of IMPDH in human stomach tissue using IMPDH antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Am, Bv, Ca, Ch, ChHa, Eq, GP, Op, Pm, RbSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

IMP Dehydrogenase 2/IMPDH2 Antibody Summary

Immunogen
Amino acids 221-248 from human IMPDH was used as the immunogen for this antibody.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
IMPDH2
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot 2-4ug/ml~
  • Immunohistochemistry 5ug/ml
  • Immunohistochemistry-Paraffin

Reactivity Notes

The amino acid sequence used as immunogen for this antibody is 100% homologous in human, mouse, rat, sumatran orangutan, white-cheeked gibbon, rhesus monkey, new world monkey, panda, cow, guinea pig, dog, chinese hamster, zebrafish, horse, chicken, african bush elephant, wild turkey, opossum, platypus, cichlid fish, rabbit, chimpanzee, salmon, pig, zebra finch, and frog.This antibody will detect both IMPDH1 and IMPDH2 in test samples. Additionally, there are multiple isoforms of the IMPDH protein. Researchers are encouraged to use a tool such as NCBI BLAST to determine theoretical sizes of, and cross reaction with, the various isoforms.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A purified

Alternate Names for IMP Dehydrogenase 2/IMPDH2 Antibody

  • EC 1.1.1.205
  • IMDH2
  • IMP (inosine 5'-monophosphate) dehydrogenase 2
  • IMP (inosine monophosphate) dehydrogenase 2
  • IMP Dehydrogenase 2
  • IMP Oxireductase 2
  • IMPD 2
  • IMPD2
  • IMPD2IMP oxireductase 2
  • IMPDH 2
  • IMPDH2
  • IMPDH-II
  • inosine 5' phosphate dehydrogenase 2
  • inosine monophosphate dehydrogenase type II
  • inosine-5'-monophosphate dehydrogenase 2

Background

IMPDH, inosine monophosphate dehydrogenase, has been demonstrated to mediate negative regulation of Toll-like receptor 2 activity via the NF-kB signaling pathway (1). IMPDH upregulates phosphatase activity of SHP-1 which then goes on to inactivate PI3-k. The central function of IMPDH in the regulation of guanosine nucleotide pathways- conversion of IMP- inosine monophosphate to XMP-xanthosine monophosphate is a critical controlling step in de novo synthesis of guanosine nucleotides in T and B lymphocytes affecting proliferation (2). Because of this, IMPDH specific detection and control has made it a target for immunosuppressive, anti-cancer, anti-parasitic, or anti-viral therapy (3). Monitoring IMPDH or IMPDH2 activity as a biomarker for mycophenolic acid-induced immunosuppression in renal transplants is one such use of IMPDH or IMPDH2 specific probes (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IMPDH2
Entrez
Uniprot