IMP Dehydrogenase 2/IMPDH2 Products

Description

IMPDH2 encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

Bioinformatics

Entrez	3615 Human
Uniprot	AAH12840 Human NM_000884 Human NP_000875 Human NP_000875.2 Human P12268 Human
Product By Gene ID	3615
Alternate Names	EC 1.1.1.205 IMP (inosine 5'-monophosphate) dehydrogenase 2 IMP (inosine monophosphate) dehydrogenase 2 IMP dehydrogenase 2 IMPD 2 IMPD2IMP oxireductase 2 IMPDH 2 IMPDH-II inosine 5' phosphate dehydrogenase 2 inosine monophosphate dehydrogenase type II inosine-5'-monophosphate dehydrogenase 2

Research Areas for IMP Dehydrogenase 2/IMPDH2

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Lipid and Metabolism