IL-7R alpha/CD127 Products

Description

Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. The human and mouse sequence is nearly identical. In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged.

Bioinformatics

Entrez	16197 Mouse 294797 Rat 3575 Human
Uniprot	AAH67539 Human AAH67539.1 Human C34791 Human NM_002185 Human P16871 Human P16872 Mouse P31749 Human
Product By Gene ID	3575
Alternate Names	CD127 antigen CD127ILRA CDW127 CDw127 IL-7 receptor subunit alpha IL-7R subunit alpha IL7RA IL-7RA IL-7R-alpha interleukin 7 receptor alpha chain interleukin 7 receptor isoform H5-6 interleukin 7 receptor interleukin-7 receptor subunit alpha

Research Areas for IL-7R alpha/CD127

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cytokine Research
Immunology
Innate Immunity
Phospho-Specific