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MAB050R) coated plate, when Recombinant Human IL-7R alpha/CD127 His-tag (Catalog # 10758-IR) is present at 500 ng/mL, Recombinant Human IL-7 (207-IL) binds with an ED50 of 0.75-4.5 ng/mL." class="big_lightbox" target="_blank">
207-IL), Recombinant Human IL-7R alpha/CD127 (Extracellular Domain) Fc Chimera Protein (Catalog # 10531-IR) binds with an ED50 of 5-30 ng/mL." class="big_lightbox" target="_blank">
10531-IR) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 78-100 kDa and 156-200 kDa, respectively." class="big_lightbox" target="_blank">
Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. The human and mouse sequence is nearly identical. In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged.
![N/A IL-7R alpha/CD127 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_IL7_R_alpha_DY747_ELISA_2212.jpg)
![Binding Activity IL-7R alpha/CD127 [Unconjugated]](http://images.novusbio.com/images/protein/10531-ir_recombinant-human-il-7r-alpha-cd127-fc-chimera-protein-cf-binding-activity-772020153152.jpg)
![Flow Cytometry IL-7R alpha/CD127 Antibody (40131) [Unconjugated]](http://images.novusbio.com/images/antibody/IL7_R_alpha_MAB306_Flow_Cytometry_19053.jpg)
![Western Blot IL-7R alpha/CD127 Antibody (40131) [Unconjugated]](http://images.novusbio.com/fullsize/mab306_human-il-7-r-alpha-cd127-mab-clone-40131-4120241252118.jpg)
![Binding Activity IL-7R alpha/CD127 [Unconjugated]](http://images.novusbio.com/images/10758-ir_recombinant-human-il-7r-alpha-cd127-his-tag-protein-cf-binding-activity-2742021132613.jpg)
![SDS-Page IL-7R alpha/CD127 [Unconjugated]](http://images.novusbio.com/fullsize/10758-ir_recombinant-human-il-7r-alpha-cd127-his-tag-protein-cf-sds-page-10320211478.jpg)
![SDS-Page IL-7R alpha/CD127 [Unconjugated]](http://images.novusbio.com/images/protein/10531-ir_recombinant-human-il-7r-alpha-cd127-fc-chimera-protein-cf-sds-page-862020154543.jpg)
