IL-17RA/IL-17R Antibody (657603) [Allophycocyanin]

EL-4 mouse lymphoblast cell line was stained with Rat Anti-Mouse IL-17 RA/IL-17 R APC-conjugated Monoclonal Antibody (Catalog # FAB4482A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Mu
• Applications: Flow
• Clone: 657603
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Allophycocyanin

IL-17RA/IL-17R Antibody (657603) [Allophycocyanin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse IL-17 R
  Ser32-Trp322
  Accession # Q60943
• Specificity: Detects mouse IL-17 R in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human IL-17 R, recombinant mouse (rm) IL-17 RB, rmIL-17 RD, or rmIL-17 RC is observed. In Western blots, less than 10% cross‑reactivity with recombinant human (rh) IL-17 R or rhIL-17 RB is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: IL17RA
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-17RA/IL-17R Antibody (657603) [Allophycocyanin]

• CD217 antigen
• CD217
• Cdw217
• CDw217interleukin 17 receptor
• hIL-17R
• IL-17 R
• IL-17 RA
• IL-17 receptor A
• IL17RA
• IL-17RA
• IL-17RAMGC10262
• IL17Rinterleukin-17 receptor A
• interleukin 17 receptor A

Background

IL-17 R, also known as IL-17 RA, is a widely expressed 120 kDa glycosylated type I transmembrane protein that plays a central role in inflammatory responses. IL‑17 R associates with IL-17 RC to form a signaling receptor complex for IL-17 and IL-17F. IL-17 R ligation promotes T cell activation and the production of IL-6, G‑CSF, SCF, and multiple proinflammatory chemokines. Within the ECD, mouse IL-17 R shares 84% and 72% aa sequence identity with rat and human IL17 R, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IL-17RA/IL-17R Antibody (FAB4482A)(1)

Publication using FAB4482A

• J Yan, Y Li, H Yang, L Zhang, B Yang, M Wang, Q Li Interleukin-17A participates in podocyte injury by inducing IL-1? secretion through ROS-NLRP3 inflammasome-caspase-1 pathway Scand. J. Immunol., 2018-03-05;0(0):. 2018-03-05 [PMID: 29446486] (Flow Cytometry, Mouse)

Bioinformatics

• Gene Symbol: IL17RA
• Uniprot:
  • Q60943()