IL-17C Antibody (177114) [Unconjugated]

Images

 
IL‑17C was detected in immersion fixed paraffin-embedded sections of human psoriatic skin using Mouse Anti-Human IL‑17C Monoclonal Antibody (Catalog # MAB1234) at 15 µg/mL overnight at 4 °C. Tissue was ...read more
PC‑3 human prostate cancer cell line was stained with Mouse Anti-Human IL‑17C Monoclonal Antibody (Catalog # MAB1234, filled histogram) or isotype control antibody (Catalog # MAB003, open histogram), followed by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, CyTOF-ready, ELISA(Cap), ICFlow
Clone
177114
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

IL-17C Antibody (177114) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human IL‑17C
His19-Val197
Accession # Q9P0M4.1
Specificity
Detects human IL-17C in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human IL-17A, B, D, E or F is observed.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
IL17C
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Immunohistochemistry 5-25 ug/mL
  • CyTOF-ready
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells
  • ELISA Standard (Matched Pair)
Application Notes
ELISA Capture: Human IL-17C Antibody (Catalog # MAB1234)
ELISA Detection: Human IL-17C Biotinylated Antibody (Catalog # BAF1234)
Standard: Recombinant Human IL-17C (Catalog # 1234-IL)
Publications
Read Publication using
MAB1234 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-17C Antibody (177114) [Unconjugated]

  • CX2
  • Cytokine CX2
  • IL17C
  • IL-17C
  • IL-17CMGC126884
  • interleukin 17C
  • interleukin-17C
  • MGC138401

Background

The Interleukin-17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus (1, 2). With the exception of IL-17B, which exists as a non‑covalently linked dimer, all IL‑17 family members are disulfide-linked dimers (3). IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1, 2). Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members, have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL‑17 RE, have also been reported (1‑4). Human IL-17C cDNA encodes a 197 amino acid (aa) residues protein with a putative 18 aa signal peptide (5). IL-17C shares from 15%‑30% aa sequence identity with other IL-17 family members. Human and mouse IL-17C also share 83% aa sequence identity. IL-17C has a very restricted expression pattern and was detected as a rare expressed sequence tag (EST) sequence in an adult prostate and fetal kidney libraries (2). IL-17C has been shown to stimulate the release of TNF-alpha and IL-1 beta from the monocytic cell line THP-1, a property it shares with IL-17B (5, 6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-17C Antibody (MAB1234)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC Paraffin-embedded.


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IHC Paraffin-embedded
(1)
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Secondary Antibodies

 

Isotype Controls

Additional IL-17C Products

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Diseases for IL-17C Antibody (MAB1234)

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Bioinformatics

Gene Symbol IL17C
Entrez
Uniprot