IL-17RA/IL-17R Products

Description

IL17RA is a gene that codes for a widely expressed protein that functions as a receptor for IL17A (a proinflammatory cytokine secreted by T-lymphocytes) with low affinity, which suggests that additional components are necessary to induce signaling and has a length of 866 amino acids and a weight of approximately 96 kDa. Current studies are being done on several diseases and disorders related to this gene including rheumatoid arthritis, cat eye syndrome, candidiasis, pituitary adenoma, bronchiolitis, cystic fibrosis, Sjogren's syndrome, keratitis, myocarditis, hepatitis B, liver disease, gingivitis, and osteoarthritis. IL17RA has also been shown to have interactions with IL17F, IL17RE, UBC, and TRAF3IP2 in pathways such as the IL-21 signaling, NF-kappaB signaling, and cytokine production pathways.

Bioinformatics

Entrez	16172 Mouse 23765 Human 312679 Rat
Uniprot	AAH11624.1 Human NP_032385.1 Mouse NP_055154 Human Q96F46 Human
Product By Gene ID	23765
Alternate Names	CD217 antigen CD217 CDw217interleukin 17 receptor hIL-17R IL-17 receptor A IL-17RAMGC10262 IL17Rinterleukin-17 receptor A interleukin 17 receptor A