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DY275). CXCL1/GROa secretion elicited by Recombinant Human IL-17/IL-17A (40 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human IL-17 RA/IL-17 R Monoclonal Antibody (Catalog # MAB177). The ND50 is typically 0.4-2 µg/mL." class="big_lightbox" target="_blank">
MAB002, open histogram) followed by anti-Mouse IgG PE-conjugated secondary antibody (F0102B). No staining in the IL-17 RA/IL-17 R knockout K562 cell line was observed. View our protocol for Staining Membrane-associated Proteins." class="big_lightbox" target="_blank">
MAB006, open histo-gram), followed by Allophycocyanin-conjugated Anti-Rat IgG Secondary Antibody (Catalog # F0113)." class="big_lightbox" target="_blank">
421-ML) induces IL-6 secretion in the NIH-3T3 mouse embryonic fibroblast cell line in a dose-dependent manner (orange line), as measured by the Mouse IL-6 Quantikine kit (Catalog # M6000B). IL-6 secretion elicited by Recombinant Mouse IL-17 (10 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL-17 RA/IL-17 R Monoclonal Antibody (Catalog # MAB4481). The ND50 is typically 0.2-0.8 µg/mL." class="big_lightbox" target="_blank">
IL17RA is a gene that codes for a widely expressed protein that functions as a receptor for IL17A (a proinflammatory cytokine secreted by T-lymphocytes) with low affinity, which suggests that additional components are necessary to induce signaling and has a length of 866 amino acids and a weight of approximately 96 kDa. Current studies are being done on several diseases and disorders related to this gene including rheumatoid arthritis, cat eye syndrome, candidiasis, pituitary adenoma, bronchiolitis, cystic fibrosis, Sjogren's syndrome, keratitis, myocarditis, hepatitis B, liver disease, gingivitis, and osteoarthritis. IL17RA has also been shown to have interactions with IL17F, IL17RE, UBC, and TRAF3IP2 in pathways such as the IL-21 signaling, NF-kappaB signaling, and cytokine production pathways.
![Flow Cytometry IL-17RA/IL-17R Antibody (133617) [Unconjugated]](http://images.novusbio.com/images/antibody/IL17_RA_MAB177_CyTOFready_23136.jpg)
![Sandwich ELISA IL-17RA/IL-17R Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-17RA-IL-17R-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79318-img0001.jpg)
![N/A IL-17RA/IL-17R [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_IL17_RA_DY177_ELISA_1713.jpg)
![Neutralization IL-17RA/IL-17R Antibody (133617) [Unconjugated]](http://images.novusbio.com/images/antibody/IL17_RA_MAB177_Block_Neutralize_15487.jpg)
![Knockout Validated IL-17RA/IL-17R Antibody (133617) [Unconjugated]](http://images.novusbio.com/images/antibody/IL17_RA_MAB177_Knockout_Validated_23137.jpg)
![SEC-MALS IL-17RA/IL-17R [Unconjugated]](http://images.novusbio.com/fullsize/11234-ir_recombinant-human-il-17ra-il-17r-his-tag-protein-cf-sec-mals-26820251035.jpg)
![Bioactivity IL-17RA/IL-17R [Unconjugated]](http://images.novusbio.com/images/11234-ir_recombinant-human-il-17ra-il-17r-his-tag-protein-cf-bioactivity-181020229523.jpg)
![SDS-Page IL-17RA/IL-17R [Unconjugated]](http://images.novusbio.com/fullsize/11234-ir_recombinant-human-il-17ra-il-17r-his-tag-protein-cf-sds-page-48202213819.jpg)
![SEC-MALS IL-17RA/IL-17R [Unconjugated]](http://images.novusbio.com/fullsize/11342-ir_recombinant-cynomolgus-monkey-il-17ra-il-17r-his-protein-cf-sec-mals-158202591036.jpg)
![Bioactivity IL-17RA/IL-17R [Unconjugated]](http://images.novusbio.com/images/11342-ir_recombinant-cynomolgus-monkey-il-17ra-il-17r-his-protein-cf-bioactivity-271202385338.jpg)
![SDS-Page IL-17RA/IL-17R [Unconjugated]](http://images.novusbio.com/fullsize/11342-ir_recombinant-cynomolgus-monkey-il-17ra-il-17r-his-protein-cf-sds-page-271202392236.jpg)
