Human Serpin A1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Serpin A1 DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: SERPINA1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Serpin A1 DuoSet ELISA, 15 Plate

• A1A
• A1AT
• AATMGC23330
• alpha 1-Antitrypsin
• alpha 1-Proteinase Inhibitor
• Alpha-1 protease inhibitor
• Alpha-1-antiproteinase
• alpha-1-antitrypsin
• antitrypsin), member 1
• member 1
• PIMGC9222
• serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
• serine (or cysteine) proteinase inhibitor, clade A, member 1
• Serpin A1
• serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Publications for Serpin A1/alpha 1-Antitrypsin (DY1268)(14)

Publications using DY1268

• P Konstanti, M van Splunt, E van den Br, C Belzer, A Nauta, RJJ van Neerve, H Smidt The Effect of Nutritional Intervention with Lactoferrin, Galactooligosacharides and Vitamin D on the Gut Microbiota Composition of Healthy Elderly Women Nutrients, 2022;14(12):. 2022 [PMID: 35745198] (Human)
• DL Frey, C Bridson, S Dittrich, SY Graeber, M Stahl, S Wege, F Herth, O Sommerburg, C Schultz, A Dalpke, MA Mall, S Boutin Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis Frontiers in Microbiology, 2022;13(0):885822. 2022 [PMID: 35633718] (Human)
• S Cambier, M Metzemaeke, AC Carvalho, A Nooyens, C Jacobs, L Vanderbeke, B Malengier-, M Gouwy, E Heylen, P Meersseman, G Hermans, E Wauters, A Wilmer, C Consortium, D Schols, P Matthys, G Opdenakker, RE Marques, J Wauters, J Vandooren, P Proost Atypical response to bacterial co-infection and persistent neutrophilic broncho-alveolar inflammation distinguish critical COVID-19 from influenza JCI Insight, 2021;0(0):. 2021 [PMID: 34793331] (Human)
• T Nakagiri, S Wrenger, K Sivaraman, F Ius, T Goecke, P Zardo, V Grau, T Welte, A Haverich, AK Knöfel, S Janciauski alpha1-Antitrypsin attenuates acute rejection of orthotopic murine lung allografts Respiratory Research, 2021;22(1):295. 2021 [PMID: 34789247] (Mouse)
• L Ostermann, R Maus, J Stolper, L Schütte, K Katsarou, S Tumpara, A Pich, C Mueller, S Janciauski, T Welte, UA Maus Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice JCI Insight, 2021;6(3):. 2021 [PMID: 33554955] (Mouse)
• M Golizeh, K Winter, L Roussel, M Landekic, M Langelier, VG Loo, M Ndao, DC Vinh Fecal host biomarkers predicting severity of Clostridioides difficile infection JCI Insight, 2020;0(0):. 2020 [PMID: 33232301] (Mouse)
• DM de Graaf, M Jaeger, ICL van den Mu, RT Horst, K Schraa, J Zwaag, M Kox, M Fujita, T Yamauchi, L Mercurio, S Madonna, JHW Rutten, J de Graaf, NP Riksen, FL van de Vee, MG Netea, LAB Joosten, CA Dinarello Reduced concentrations of the B cell cytokine Interleukin 38 are associated with cardiovascular disease risk in overweight subjects Eur J Immunol, 2020;0(0):. 2020 [PMID: 33125159] (Human)
• J Cassuto, A Folestad, J Göthlin, H Malchau, J Kärrholm Concerted actions by MMPs, ADAMTS and serine proteases during remodeling of the cartilage callus into bone during osseointegration of hip implants Bone Rep, 2020;13(0):100715. 2020 [PMID: 32995386] (Human)
• K Ogawa, T Kobayashi, JI Furukawa, H Hanamatsu, A Nakamura, K Suzuki, N Kawagishi, M Ohara, M Umemura, M Nakai, T Sho, G Suda, K Morikawa, M Baba, K Furuya, K Terashita, T Kobayashi, M Onodera, T Horimoto, K Shinada, S Tsunematsu, I Tsunematsu, T Meguro, T Mitsuhashi, M Hato, K Higashino, Y Shinohara, N Sakamoto Tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis: a novel glycobiomarker for non-alcoholic steatohepatitis Sci Rep, 2020;10(1):321. 2020 [PMID: 31941930] (Human)
• EP Reeves, DM Dunlea, K McQuillan, CA O'Dwyer, TP Carroll, R Saldova, PR Akepati, MR Wormald, OJ McElvaney, V Shutchaida, M Henry, P Meleady, J Keenan, DC Liberti, DN Kotton, PM Rudd, AA Wilson, NG McElvaney Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity J. Immunol., 2019;0(0):. 2019 [PMID: 30796179] (Human)
• T Kubo, M Tsujiwaki, Y Hirohashi, T Tsukahara, T Kanaseki, M Nakatsugaw, T Hasegawa, T Torigoe Differential bronchial epithelial response regulated by ?Np63: a functional understanding of the epithelial shedding found in asthma Lab. Invest., 2018;0(0):. 2018 [PMID: 30254318] (Human)
• Ramnik J Xavier Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity Cell, 2016;167(4):1125-1136.e8. 2016 [PMID: 27814509] (Human)
• Mihai G Netea Host and Environmental Factors Influencing Individual Human Cytokine Responses Cell, 2016;167(4):1111-1124.e13. 2016 [PMID: 27814508] (Human)
• Zager R, Johnson A, Frostad K Rapid renal alpha-1 antitrypsin gene induction in experimental and clinical acute kidney injury. PLoS ONE, 2014;9(5):e98380. 2014 [PMID: 24848503] (Human)

Bioinformatics

• Gene Symbol: SERPINA1