Human Phospho-EphB4 DuoSet IC ELISA, 2 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Phospho-EphB4 DuoSet IC ELISA, 2 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: EPHB4

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Phospho-EphB4 DuoSet IC ELISA, 2 Plate

• EC 2.7.10
• EC 2.7.10.1
• EPH receptor B4
• EphB4
• ephrin type-B receptor 4
• hepatoma transmembrane kinase
• Htk
• HTKephrin receptor EphB4
• Mdk2
• Myk1
• soluble EPHB4 variant 1
• soluble EPHB4 variant 2
• soluble EPHB4 variant 3
• Tyro11
• Tyrosine-protein kinase receptor HTK
• Tyrosine-protein kinase TYRO11

Background

Cell migration is influenced by chemodirectants including a large family of receptor tyrosine kinases collectively referred to as Ephs. Ephs are divided into two classes based on their extracellular structure and ligand specificity. Eph receptors that bind preferentially to ephrin-B ligands are referred to as EphB. All Eph receptors contain an N-terminal Ig-like domain, a cysteine-rich region with 19 conserved cysteines and two fibronectin type III domains. The cytoplasmic region contains a typical tyrosine kinase organization.

Publications for EphB4 (DYC4057-2)(5)

Publications using DYC4057-2

• Abdelazeem, KNM;Nguyen, D;Corbo, S;Darragh, LB;Matsumoto, MW;Van Court, B;Neupert, B;Yu, J;Olimpo, NA;Osborne, DG;Gadwa, J;Ross, RB;Nguyen, A;Bhatia, S;Kapoor, M;Friedman, RS;Jacobelli, J;Saviola, AJ;Knitz, MW;Pasquale, EB;Karam, SD; Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC Oncogene 2024-11-03 [PMID: 39489818] (Human)
• C You, K Zhao, P Dammann, K Keyvani, I Kreitschma, U Sure, Y Zhu EphB4 forward signalling mediates angiogenesis caused by CCM3/PDCD10-ablation J. Cell. Mol. Med., 2017-04-01;0(0):. 2017-04-01 [PMID: 28371279] (Human)
• Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas Sci Rep, 2016-12-12;6(0):38792. 2016-12-12 [PMID: 27941840] (Human)
• Giorgio C, Hassan Mohamed I, Flammini L, Barocelli E, Incerti M, Lodola A, Tognolini M Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation. PLoS ONE, 2011-03-30;6(3):e18128. 2011-03-30 [PMID: 21479221] (Human)
• Pennisi A, Ling W, Li X, Khan S, Shaughnessy JD, Barlogie B, Yaccoby S The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth. Blood, 2009-07-13;114(9):1803-12. 2009-07-13 [PMID: 19597185] (Human)

Bioinformatics

• Gene Symbol: EPHB4